CAS 870281-82-6

Idelalisib

Description:

Idelalisib is a selective inhibitor of phosphoinositide 3-kinase (PI3K) delta, primarily used in the treatment of certain types of hematological malignancies, particularly chronic lymphocytic leukemia (CLL) and follicular lymphoma. Its chemical formula is C19H19ClN2O4S, and it features a chlorobenzene ring, a pyrimidine moiety, and a sulfonamide group, which contribute to its pharmacological activity. Idelalisib works by disrupting the signaling pathways that promote cell proliferation and survival in malignant B cells. The substance is administered orally and is known for its potential side effects, including diarrhea, liver function abnormalities, and immune-related adverse events. As a targeted therapy, idelalisib represents a significant advancement in the treatment of specific cancers, offering a more focused approach compared to traditional chemotherapy. Its development underscores the importance of molecular targeting in oncology, aiming to improve patient outcomes while minimizing systemic toxicity.

Formula: C₂₂H₁₈FN₇O

InChI: InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1

InChI key: InChIKey=IFSDAJWBUCMOAH-HNNXBMFYSA-N

SMILES: [C@H](NC1=C2C(N=CN2)=NC=N1)(CC)C=3N(C(=O)C=4C(N3)=CC=CC4F)C5=CC=CC=C5

Synonyms:

• (S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
• 4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]-
• 4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-
• 5-Fluoro-3-Phenyl-2-[(1S)-1-(9H-Purin-6-Ylamino)Propyl]-4(3H)-Quinazolinone
• Cal-101
• Delalisib
• Gs-1101
• Idelalisib
• N⁶-[(S)-1-(5-Fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl]adenine
• Zydelig

4(3H)-Quinazolinone,5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylamino)propyl]-

CAS: 870281-82-6

Formula: C₂₂H₁₈FN₇O

Purity: 98%

Color and Shape: Solid

Molecular weight: 415.4230

Ref: IN-DA00GU21

5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone

CAS: 870281-82-6

5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone

Purity: 98%

Molecular weight: 415.42g/mol

Ref: 54-PC105287

Idelalisib

CAS: 870281-82-6

Formula: C₂₂H₁₈FN₇O

Color and Shape: White To Off-White Solid

Molecular weight: 415.43

Ref: 4Z-I-084001

Idelalisib

CAS: 870281-82-6

Idelalisib

Formula: C₂₂H₁₈FN₇O

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 415.42

Ref: 54-BUP15552

Idelalisib

CAS: 870281-82-6

Color and Shape: Light Brown

Ref: 86-MM3789.00

Idelalisib-d5

CAS: 870281-82-6

Formula: C₂₂H₁₃FN₇OD₅

Molecular weight: 420.46

Ref: 4Z-I-084002

Idelalisib

CAS: 870281-82-6

(S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

Formula: C₂₂H₁₈FN₇O

Purity: 98%

Molecular weight: 415.42

Ref: IN-DG224801

Idelalisib

CAS: 870281-82-6

Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).

Formula: C₂₂H₁₈FN₇O

Purity: 98% - 99.39%

Color and Shape: White Solid

Molecular weight: 415.42

Ref: TM-T1894

CAL-101

Controlled Product

CAS: 870281-82-6

Applications CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor.
References Airiau, K. et al.: Cell. Death. Dis., 4, e827 (2013); Kulesz-Martin, M. et al Canc. Biol. Ther., 14m 95 (2013);

Formula: C₂₂H₁₈FN₇O

Color and Shape: Neat

Molecular weight: 415.4

Ref: TR-C124800

Idelalisib

CAS: 870281-82-6

Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.

Formula: C₂₂H₁₈FN₇O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 415.42 g/mol

Ref: 3D-FI29231

Idelalisib

CAS: 870281-82-6

Ref: BE-RMCI020000

CAL-101-d5

Controlled Product

CAS: 870281-82-6

Formula: C₂₂D₅H₁₃FN₇O

Color and Shape: Neat

Molecular weight: 420.454

Ref: TR-C124802

Idelalisib

CAS: 870281-82-6

Formula: C₂₂H₁₈FN₇O

Molecular weight: 415.43

Ref: ST-EA-CP-I46000