CAS 871224-64-5

Almorexant

Description:

Almorexant is a chemical compound classified as a dual orexin receptor antagonist, primarily investigated for its potential use in treating insomnia and other sleep disorders. It functions by selectively blocking the action of orexin neuropeptides, which play a crucial role in regulating arousal, wakefulness, and appetite. The molecular structure of Almorexant features a complex arrangement that contributes to its pharmacological activity, although specific details about its physical properties, such as solubility and stability, are typically found in specialized databases or scientific literature. Almorexant has undergone various clinical trials to assess its efficacy and safety profile, demonstrating promise in promoting sleep without the adverse effects commonly associated with traditional sedatives. As with many investigational drugs, its development status may vary, and ongoing research continues to explore its full therapeutic potential and mechanism of action.

Formula: C₂₉H₃₁F₃N₂O₃

InChI: InChI=1S/C29H31F3N2O3/c1-33-28(35)27(20-7-5-4-6-8-20)34-16-15-21-17-25(36-2)26(37-3)18-23(21)24(34)14-11-19-9-12-22(13-10-19)29(30,31)32/h4-10,12-13,17-18,24,27H,11,14-16H2,1-3H3,(H,33,35)/t24-,27+/m0/s1

InChI key: InChIKey=DKMACHNQISHMDN-RPLLCQBOSA-N

SMILES: C(CC1=CC=C(C(F)(F)F)C=C1)[C@H]2C=3C(=CC(OC)=C(OC)C3)CCN2[C@@H](C(NC)=O)C4=CC=CC=C4

Synonyms:

• (R)-2-((R)-6,7-Dimethoxy-1-(4-(Trifluoromethyl)Phenethyl)-3,4-Dihydroisoquinolin-2(1H)-Yl)-N-Methyl-2-Phenylacetamide
• (αR,1S)-3,4-Dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-2(1H)-isoquinolineacetamide
• 2(1H)-Isoquinolineacetamide, 3,4-dihydro-6,7-dimethoxy-N-methyl-α-phenyl-1-[2-[4-(trifluoromethyl)phenyl]ethyl]-, (αR,1S)-
• Act-078573
• Act-078573(R)-2-((R)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• Almorexant
• AlMorexant (hydrochloride)
• CS-1665
• almorexant (ACT-078573), CID 23727689
• ACT-078573;ACT 078573;ACT078573
• (2R)-2-((1S)-6,7-Dimethoxy-1-{2-(4-(trifluoromethyl)phenyl)ethyl}-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• almorexant (ACT-078573)
• 2-(6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide
• (2R)-2-[(1S)-6,7-DIMETHOXY-1-[2-[4-(TRIFLUOROMETHYL)PHENYL]ETHYL]-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL]-N-METHYL-2-PHENYLACETAMIDE
• Almorexant [inn]
• AlMorexant HCl

Almorexant

CAS: 871224-64-5

Almorexant

Formula: C₂₉H₃₁F₃N₂O₃

Purity: ≥95%

Molecular weight: 512.56

Ref: 54-BUP03376

Almorexant-13C-d3

CAS: 871224-64-5

Formula: C₂₈₁₃CH₂₈D₃F₃N₂O₃

Color and Shape: Pale Yellow Solid

Molecular weight: 516.58

Ref: 4Z-A-201002

Almorexant

CAS: 871224-64-5

Formula: C₂₉H₃₁F₃N₂O₃

Color and Shape: Pale Yellow Solid

Molecular weight: 512.58

Ref: 4Z-A-201001

Almorexant

CAS: 871224-64-5

Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.

Formula: C₂₉H₃₁F₃N₂O₃

Purity: 97.75% - 98.02%

Color and Shape: Solid

Molecular weight: 512.56

Ref: TM-T2613

Almorexant

CAS: 871224-64-5

(R)-2-((S)-6,7-dimethoxy-1-(4-(trifluoromethyl)phenethyl)-3,4-dihydroisoquinolin-2(1H)-yl)-N-methyl-2-phenylacetamide

Formula: C₂₉H₃₁F₃N₂O₃

Purity: 98%

Molecular weight: 512.56

Ref: IN-DG47339

Almorexant

CAS: 871224-64-5

Ref: BE-RMCA128000

Almorexant

CAS: 871224-64-5

Formula: C₂₉H₃₁F₃N₂O₃

Molecular weight: 512.58

Ref: ST-EA-CP-A313002