CAS 871543-07-6

Formula: C16H23Cl2N3O2S

InChI: InChI=1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m0../s1

InChI key: BFOPDSJOLUQULZ-GXKRWWSZSA-N

SMILES: C[C@H]1CNCCCN1S(=O)(=O)C2=CC=CC3=C2C(=CN=C3)C.Cl.Cl

H-1152 (dihydrochloride)

CAS: 871543-07-6

Formula: C₁₆H₂₃Cl₂N₃O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 392.3437

Ref: IN-DA008F7I

H-1152 dihydrochloride

CAS: 871543-07-6

H-1152 dihydrochloride

Formula: C₁₆H₂₃Cl₂N₃O₂S

Purity: 99.5%

Molecular weight: 392.34

Ref: 54-BUP06992

H-1152 Dihydrochloride

Controlled Product

CAS: 871543-07-6

Stability Hygroscopic
Applications ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA 9.27 mMfor PKC, and 10.1mM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC50=2.5nM) in NT-2 cells.
References Ikenoya, M., et al.: J. Neurochem., 81, 9 (2002), Sasaki, Y., et al.: Pharmacol. Ther., 93, 225 (2002)

Formula: C₁₆H₂₁N₃O₂S·2ClH

Color and Shape: Neat

Molecular weight: 392.34

Ref: TR-H011520

H-1152 2HCl

CAS: 871543-07-6

(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride

Formula: C₁₆H₂₃Cl₂N₃O₂S

Purity: 99%

Molecular weight: 392.34

Ref: IN-DG306018

H1152

CAS: 871543-07-6

Ref: 7W-GW5494

H 1152 dihydrochloride

CAS: 871543-07-6

Inhibitor of Rho-kinase

Formula: C₁₆H₂₃Cl₂N₃O₂S

Purity: Min. 95%

Molecular weight: 392.34 g/mol

Ref: 3D-FD22031

H-1152 dihydrochloride

CAS: 871543-07-6

H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.

Formula: C₁₆H₂₃Cl₂N₃O₂S

Purity: 99.85%

Color and Shape: White Solid

Molecular weight: 392.34

Ref: TM-T35328