CAS 872728-81-9

Dabigatran etexilate mesylate

Description:

Dabigatran etexilate mesylate is an oral anticoagulant medication primarily used for the prevention and treatment of thromboembolic disorders, such as atrial fibrillation and deep vein thrombosis. It is a prodrug that is converted in the body to its active form, dabigatran, which directly inhibits thrombin, a key enzyme in the coagulation cascade. This inhibition prevents the conversion of fibrinogen to fibrin, thereby reducing clot formation. The substance is characterized by its high bioavailability and rapid onset of action, making it effective for acute and chronic management of clotting disorders. Dabigatran etexilate mesylate is typically administered in capsule form and is known for its predictable pharmacokinetics, which allows for fixed dosing without routine monitoring of coagulation parameters. It is important to note that, like other anticoagulants, it carries a risk of bleeding, and its use may be contraindicated in certain populations, such as those with severe renal impairment. Overall, dabigatran etexilate mesylate represents a significant advancement in anticoagulant therapy.

Formula: C₃₄H₄₁N₇O₅·CH₄O₃S

InChI: InChI=1S/C34H41N7O5.CH4O3S/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29;1-5(2,3)4/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44);1H3,(H,2,3,4)

InChI key: InChIKey=XETBXHPXHHOLOE-UHFFFAOYSA-N

SMILES: CN1C=2C(=CC(C(N(CCC(OCC)=O)C3=CC=CC=N3)=O)=CC2)N=C1CNC4=CC=C(C(NC(OCCCCCC)=O)=N)C=C4.S(C)(=O)(=O)O

Synonyms:

• Bibr 1048Ms
• Dabigatran Etexilate Mesilate
• Dabigatran Etexilate Methanesulfonate
• Dabigatran etexilate mesylate
• N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat
• Pradaxa
• β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, methanesulfonate (1:1)
• β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, monomethanesulfonate

DABIGATRAN ETEXILATE MESILATE CRS

CAS: 872728-81-9

DABIGATRAN ETEXILATE MESILATE CRS

Ref: 41-Y0002393

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Compounds containing an unfused pyridine ring in the structure, nesoi

Formula: C₃₄H₄₁N₇O₅·CH₄O₃S

Color and Shape: White Off-White Yellow Powder

Molecular weight: 723.30503

Ref: 45-1162239

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Formula: C₃₅H₄₅N₇O₈S

Purity: 98%

Color and Shape: Solid

Molecular weight: 723.8389

Ref: IN-DA00391G

Hexyl 2-(4-(((5-((3-Ethoxy-3-Oxopropyl)(Pyridin-2-Yl)Carbamoyl)-1-Methyl-1H-Benzo[d]Imidazol-2-Yl)Methyl)Amino)Benzylidene)Hydrazinecarboxylate Methanesulfonate

CAS: 872728-81-9

Hexyl 2-(4-(((5-((3-Ethoxy-3-Oxopropyl)(Pyridin-2-Yl)Carbamoyl)-1-Methyl-1H-Benzo[d]Imidazol-2-Yl)Methyl)Amino)Benzylidene)Hydrazinecarboxylate Methanesulfonate

Purity: 98%

Molecular weight: 723.84g/mol

Ref: 54-OR1029511

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Dabigatran Etexilate Mesylate

Purity: ≥98%

Molecular weight: 723.84g/mol

Ref: 54-BUP17140

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Formula: C₃₄H₄₁N₇O₅·CH₄O₃S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 723.85

Ref: 3B-D6198

Dabigatran Etexilate Mesilate

Controlled Product

CAS: 872728-81-9

Formula: C₃₄H₄₁N₇O₅·CH₄O₃S

Color and Shape: Neat

Molecular weight: 723.84

Ref: 86-MM3522.00

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor.

Formula: C₃₄H₄₁N₇O₅·CH₄O₃S

Purity: 99.91%

Color and Shape: Solid

Molecular weight: 723.84

Ref: TM-T5133

Dabigatran Etexilate Mesylate

CAS: 872728-81-9

Formula: C₃₄H₄₁N₇O₅CH₄O₃S

Molecular weight: 627.7 : 96.1

Ref: ST-EA-CP-D5074

Dabigatran Etexilate Mesylate

Controlled Product

CAS: 872728-81-9

Applications Nonpeptide, direct thrombin inhibitor. Antithrombotic.
References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),

Formula: C₃₄H₄₁N₇O₅·CH₄O₃S

Color and Shape: Light Yellow

Molecular weight: 723.84

Ref: TR-D100150

Dabigatran etexilate mesylate

CAS: 872728-81-9

Dabigatran etexilate mesylate is an anticoagulant that is a prodrug of dabigatran, which is not active in the body. It is a synthetic molecule that has been designed to be rapidly converted into dabigatran by esterases in the blood plasma. Dabigatran etexilate mesylate has been shown to have a high bioavailability and low clearance rate, as well as good oral absorption and stability. The drug can be used for people with impaired liver function who are being treated with warfarin or heparin, without any change in dosage requirements. The antidote for dabigatran etexilate mesylate is idarucizumab, which binds to dabigatran in the bloodstream and prevents its binding to thrombin receptors on the surface of blood cells.

Formula: C₃₅H₄₅N₇O₈S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 723.84 g/mol

Ref: 3D-FD20773