CAS 872728-81-9: Dabigatran etexilate mesylate
Description:Dabigatran etexilate mesylate is an oral anticoagulant medication primarily used for the prevention and treatment of thromboembolic disorders, such as atrial fibrillation and deep vein thrombosis. It is a prodrug that is converted in the body to its active form, dabigatran, which directly inhibits thrombin, a key enzyme in the coagulation cascade. This inhibition prevents the conversion of fibrinogen to fibrin, thereby reducing clot formation. The substance is characterized by its high bioavailability and rapid onset of action, making it effective for acute and chronic management of clotting disorders. Dabigatran etexilate mesylate is typically administered in capsule form and is known for its predictable pharmacokinetics, which allows for fixed dosing without routine monitoring of coagulation parameters. It is important to note that, like other anticoagulants, it carries a risk of bleeding, and its use may be contraindicated in certain populations, such as those with severe renal impairment. Overall, dabigatran etexilate mesylate represents a significant advancement in anticoagulant therapy.
Formula:C34H41N7O5·CH4O3S
InChI:InChI=1S/C34H41N7O5.CH4O3S/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29;1-5(2,3)4/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44);1H3,(H,2,3,4)
InChI key:InChIKey=XETBXHPXHHOLOE-UHFFFAOYSA-N
SMILES:O=C(OCCCCCC)NC(=N)C1=CC=C(C=C1)NCC2=NC=3C=C(C=CC3N2C)C(=O)N(C4=NC=CC=C4)CCC(=O)OCC.O=S(=O)(O)C
- Synonyms:
- Bibr 1048Ms
- Dabigatran Etexilate Mesilate
- Dabigatran Etexilate Methanesulfonate
- Dabigatran etexilate mesylate
- N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat
- Pradaxa
- β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, methanesulfonate (1:1)
- β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, monomethanesulfonate
![Hexyl 2-(4-(((5-((3-Ethoxy-3-Oxopropyl)(Pyridin-2-Yl)Carbamoyl)-1-Methyl-1H-Benzo[d]Imidazol-2-Yl)…](https://static.cymitquimica.com/products/54/thumb/OR1029511.jpg)
