CAS 872728-81-9
:Dabigatran etexilate mesylate
Description:
Dabigatran etexilate mesylate is an oral anticoagulant medication primarily used for the prevention and treatment of thromboembolic disorders, such as atrial fibrillation and deep vein thrombosis. It is a prodrug that is converted in the body to its active form, dabigatran, which directly inhibits thrombin, a key enzyme in the coagulation cascade. This inhibition prevents the conversion of fibrinogen to fibrin, thereby reducing clot formation. The substance is characterized by its high bioavailability and rapid onset of action, making it effective for acute and chronic management of clotting disorders. Dabigatran etexilate mesylate is typically administered in capsule form and is known for its predictable pharmacokinetics, which allows for fixed dosing without routine monitoring of coagulation parameters. It is important to note that, like other anticoagulants, it carries a risk of bleeding, and its use may be contraindicated in certain populations, such as those with severe renal impairment. Overall, dabigatran etexilate mesylate represents a significant advancement in anticoagulant therapy.
Formula:C34H41N7O5·CH4O3S
InChI:InChI=1S/C34H41N7O5.CH4O3S/c1-4-6-7-10-21-46-34(44)39-32(35)24-12-15-26(16-13-24)37-23-30-38-27-22-25(14-17-28(27)40(30)3)33(43)41(20-18-31(42)45-5-2)29-11-8-9-19-36-29;1-5(2,3)4/h8-9,11-17,19,22,37H,4-7,10,18,20-21,23H2,1-3H3,(H2,35,39,44);1H3,(H,2,3,4)
InChI key:InChIKey=XETBXHPXHHOLOE-UHFFFAOYSA-N
SMILES:CN1C=2C(=CC(C(N(CCC(OCC)=O)C3=CC=CC=N3)=O)=CC2)N=C1CNC4=CC=C(C(NC(OCCCCCC)=O)=N)C=C4.S(C)(=O)(=O)O
Synonyms:- Bibr 1048Ms
- Dabigatran Etexilate Mesilate
- Dabigatran Etexilate Methanesulfonate
- Dabigatran etexilate mesylate
- N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat
- Pradaxa
- β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, methanesulfonate (1:1)
- β-Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester, monomethanesulfonate
Filter by
Purity percentage
0
100
|
0
|
50
|
90
|
95
|
100
Found 12 products.
- Lower prices
- Higher prices
- Lower purities
- Higher purities
- Faster estimated delivery
Dabigatran Etexilate Mesylate
CAS:Formula:C34H41N7O5·CH4O3SPurity:>98.0%(HPLC)(T)Color and Shape:White to Light yellow powder to crystalMolecular weight:723.85Dabigatran Etexilate Mesylate
CAS:Compounds containing an unfused pyridine ring in the structure, nesoiFormula:C34H41N7O5·CH4O3SColor and Shape:White Off-White Yellow PowderMolecular weight:723.30503Hexyl 2-(4-(((5-((3-Ethoxy-3-Oxopropyl)(Pyridin-2-Yl)Carbamoyl)-1-Methyl-1H-Benzo[d]Imidazol-2-Yl)Methyl)Amino)Benzylidene)Hydrazinecarboxylate Methanesulfonate
CAS:Hexyl 2-(4-(((5-((3-Ethoxy-3-Oxopropyl)(Pyridin-2-Yl)Carbamoyl)-1-Methyl-1H-Benzo[d]Imidazol-2-Yl)Methyl)Amino)Benzylidene)Hydrazinecarboxylate MethanesulfonateFormula:C35H45N7O8SPurity:98%Molecular weight:723.84Dabigatran Etexilate Mesylate
CAS:Dabigatran Etexilate MesylateFormula:C34H41N7O5·CH4O3SPurity:≥98%Molecular weight:723.84Dabigatran Etexilate Mesilate
CAS:Controlled ProductFormula:C34H41N7O5·CH4O3SColor and Shape:NeatMolecular weight:723.84Dabigatran Etexilate Mesylate
CAS:Controlled ProductApplications Nonpeptide, direct thrombin inhibitor. Antithrombotic.
References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),Formula:C34H41N7O5·CH4O3SColor and Shape:NeatMolecular weight:723.84Dabigatran Etexilate Mesylate
CAS:Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor.Formula:C34H41N7O5·CH4O3SPurity:99.91%Color and Shape:SolidMolecular weight:723.84Dabigatran etexilate mesylate
CAS:Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonateFormula:C35H45N7O8SPurity:98%Molecular weight:723.84Dabigatran etexilate mesylate
CAS:Dabigatran etexilate mesylate is an anticoagulant that is a prodrug of dabigatran, which is not active in the body. It is a synthetic molecule that has been designed to be rapidly converted into dabigatran by esterases in the blood plasma. Dabigatran etexilate mesylate has been shown to have a high bioavailability and low clearance rate, as well as good oral absorption and stability. The drug can be used for people with impaired liver function who are being treated with warfarin or heparin, without any change in dosage requirements. The antidote for dabigatran etexilate mesylate is idarucizumab, which binds to dabigatran in the bloodstream and prevents its binding to thrombin receptors on the surface of blood cells.
Formula:C35H45N7O8SPurity:Min. 95%Color and Shape:PowderMolecular weight:723.84 g/molDabigatran Etexilate Mesylate
CAS:Formula:C35H45N7O8SPurity:98%Color and Shape:SolidMolecular weight:723.8389
