CAS 874-60-2

4-Methylbenzoyl chloride

Description:

4-Methylbenzoyl chloride, also known as p-toluoyl chloride, is an aromatic acyl chloride characterized by its structure, which features a benzene ring substituted with a methyl group and a carbonyl chloride functional group. This compound is typically a colorless to pale yellow liquid with a pungent odor, indicative of its reactivity. It is soluble in organic solvents such as dichloromethane and ether but is not soluble in water due to its hydrophobic nature. 4-Methylbenzoyl chloride is known for its role as an acylating agent in organic synthesis, particularly in the preparation of various derivatives and intermediates in pharmaceuticals and agrochemicals. It is sensitive to moisture and can hydrolyze to form the corresponding carboxylic acid, 4-methylbenzoic acid, and hydrochloric acid upon contact with water. Safety precautions are essential when handling this compound, as it can cause severe irritation to the skin, eyes, and respiratory tract. Proper storage in a cool, dry place, away from moisture, is recommended to maintain its stability.

Formula: C₈H₇ClO

InChI: InChI=1/C8H7ClO/c1-6-2-4-7(5-3-6)8(9)10/h2-5H,1H3

InChI key: InChIKey=NQUVCRCCRXRJCK-UHFFFAOYSA-N

SMILES: C(Cl)(=O)C1=CC=C(C)C=C1

Synonyms:

• 4-Methylbenzenecarbonyl chloride
• 4-Methylbenzoic acid chloride
• 4-Methylbenzoyl chloride
• 4-Toluoyl chloride
• Chlorure de p-toluoyle
• Cloruro De P-Toluoilo
• P-Toluoyl Chloride
• p-Methylbenzoyl chloride
• p-Toluenecarbonyl chloride
• p-Toluic acid chloride
• p-Toluoylchlorid
• p-Toluyl chloride
• para-toluoyl chloride
• Benzoyl chloride, 4-methyl-
• LABOTEST-BB LTBB000520
• PTC
• 4-methylbenzoly chloride
• Benzoyl chloride, 4-methyl-(9CI)
• 4-methyl-benzoylchlorid
• 4-methylbenzoicacidchloride
• Benzoylchloride,4-methyl-
• O-TOLUENECARBONYL CHLORIDE
• p-toluicacidchloride
• 4-METHYL-BENZOYL CHLORIDE,98%
• p-Toluoylchloride,99%

p-Toluoyl Chloride

CAS: 874-60-2

Formula: C₈H₇ClO

Purity: >98.0%(GC)(T)

Color and Shape: Colorless to Light yellow clear liquid

Molecular weight: 154.59

Ref: 3B-T0311

p-Toluoyl chloride, 99%

CAS: 874-60-2

p-Toluoyl chloride was used to prepare antigen, Tolyl-amido-human serum albumin. It is used as a reagent to synthesize (+)-Yashabushitriol, derivatives of Desloratadine. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and lab

Formula: C₈H₇ClO

Purity: 99%

Color and Shape: Clear colorless to pale yellow, Liquid

Molecular weight: 154.59

Ref: 02-A15581

p-Toluoyl chloride

CAS: 874-60-2

Formula: C₈H₇ClO

Purity: 98%

Color and Shape: Liquid

Molecular weight: 154.5936

Ref: IN-DA0035JI

p-Toluoyl chloride

CAS: 874-60-2

Formula: C₈H₇ClO

Purity: 98%

Color and Shape: Liquid

Molecular weight: 154.59

Ref: 10-F099143

p-Toluoyl Chloride

CAS: 874-60-2

Formula: C₈H₇ClO

Molecular weight: 154.59

Ref: 4Z-T-6975

p-Toluoyl Chloride

CAS: 874-60-2

Formula: C₈H₇ClO

Molecular weight: 154.59

Ref: ST-EA-CP-T26065

p-Toluoyl Chloride

Controlled Product

CAS: 874-60-2

Applications p-Toluoyl chloride is an aromatic compound used as a reagent to synthesize (+)-Yashabushitriol, a plant metabolite that is naturally found in the male flowers of Alnus sieboldiana matsum. p-Toluoyl chloride is also used as a reagent to prepare derivatives of Desloratadine (D290250). Desloratadine is a selective H1-receptor antagonist that has anti-inflammatory effects and is used to treat patients with allergic rhinitis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Berger, W.. et al.: Ann. All. Asth. Immun., 89, 485 (2002); Fang, Z., et al.: Tetrahedron Lett., 54, 6834 (2013); Feldman, K. & Simpson, R.: Tetrahedron Lett., 30, 6985 (1989); Mu, S., et al.: Chin. Chem. Lett., 24, 531 (2013)

Formula: C₈H₇ClO

Color and Shape: Neat

Molecular weight: 154.59

Ref: TR-T536400