CAS 875638-86-1

Formula: C23H22N4O2

InChI: InChI=1S/C23H22N4O2/c1-27(2)23(28)18-10-14(8-9-20(18)24)15-11-17-19(13-26-22(17)25-12-15)16-6-4-5-7-21(16)29-3/h4-13H,24H2,1-3H3,(H,25,26)

InChI key: WXWRMODVCNBNEA-UHFFFAOYSA-N

SMILES: CN(C)C(=O)C1=C(C=CC(=C1)C2=CC3=C(NC=C3C4=CC=CC=C4OC)N=C2)N

HPK1-IN-61

CAS: 875638-86-1

HPK1-IN-61 (Compound 1) serves as an inhibitor of hematopoietic progenitor kinase 1 (HPK1) with a Ki of 0.4 nM, and also inhibits Abl with an IC50 of less than 0.51 nM. Additionally, HPK1-IN-61 displays inhibitory activity against LCK, with an IC50 of 24 nM.

Formula: C₂₃H₂₂N₄O₂

Color and Shape: Solid

Molecular weight: 386.45

Ref: TM-T212057