CAS 87616-84-0

(D-trp7,ala8,D-phe10)-A-melanocyte*stimulating ho

Description:

The substance known as (D-Trp7, Ala8, D-Phe10)-A-melanocyte-stimulating hormone (CAS 87616-84-0) is a synthetic analog of the naturally occurring melanocyte-stimulating hormone (MSH), which plays a crucial role in regulating pigmentation, appetite, and energy homeostasis. This peptide is characterized by its modified amino acid sequence, which includes D-amino acids at specific positions, enhancing its stability and bioactivity compared to the native hormone. The incorporation of D-Trp, Ala, and D-Phe contributes to its receptor binding affinity and biological activity, making it a valuable compound in research related to skin pigmentation and potential therapeutic applications. The structural modifications also help in reducing enzymatic degradation, thereby prolonging its action in biological systems. As a peptide, it is typically administered via injection and is of interest in studies related to dermatology and endocrinology. Its unique properties make it a subject of investigation for understanding the mechanisms of skin pigmentation and the regulation of appetite.

Formula: C₄₆H₅₆N₁₂O₆

InChI: InChI=1/C46H56N12O6/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64)/t27-,34-,37-,38?,39+,40-/m0/s1

Synonyms:

• (D-Trp7,Ala8,D-Phe10)-.alpha.-MSH (6-11)
• H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
• Ghrp-6
• L-histidyl-D-tryptophyl-L-alanyl-L-tryptophylphenylalanyl-L-lysinamide
• Growth Hormone Releasing Peptide

(D-Trp⁷,Ala⁸,D-Phe¹⁰)-α-MSH (6-11) amide

CAS: 87616-84-0

In search of competitive α-MSH antagonists, the hexapeptide GHRP-6 has been recognized as a selective inhibitor of α-MSH activity in the frog skin bioassay. It is identical in sequence with a growth hormone-releasing peptide analog, (His¹,Lys⁶)-GHRP, which selectively releases GH in vitro and in a wide variety of species in vivo. GHRP-6 also acts as a functional antagonist of somatostatin in the somatotrope cells.

Formula: C₄₆H₅₆N₁₂O₆

Purity: 98.3%

Color and Shape: Light Yellow Powder

Molecular weight: 873.03

Ref: 01-4008401

[D-Trp7, Ala8, D-Phe10]-α-Melanocyte Stimulating Hormone Amide Fragment 6-11

CAS: 87616-84-0

Formula: C₄₆H₅₆N₁₂O₆

Molecular weight: 873.01

Ref: 7W-GL7260

Hexapeptide-2

CAS: 87616-84-0

Formula: C₄₆H₅₆N₁₂O₆

Molecular weight: 873.03

Ref: 4Z-PH-097001

L-Histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide Acetate Salt

Controlled Product

CAS: 87616-84-0

Formula: C₄₆H₅₆N₁₂O₆·x(C₂H₄O₂)

Color and Shape: Neat

Molecular weight: 873.01 + x(60.05)

Ref: TR-H456210

H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

CAS: 87616-84-0

H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 is a potent activator of the human growth hormone receptor, which leads to increased levels of insulin growth factor 1 (IGF1). H-His-D-Trp-Ala-Trp-D-Phe-Lys NH2 causes an increase in locomotor activity and somatotrophs. This peptide has been shown to be effective in treating metabolic disorders such as obesity and diabetes mellitus type 2. It also has antiviral properties that may be useful for the treatment of infectious diseases, such as HIV.

Formula: C₄₆H₅₆N₁₂O₆

Purity: Min. 95%

Molecular weight: 873.04 g/mol

Ref: 3D-PGH-3694-PI

Growth hormone releasing peptide

CAS: 87616-84-0

Growth hormone releasing peptide (GHRP) is a cyclase inhibitor that blocks the release of endogenous growth hormone. This peptide acts on both igf-i and somatotrophs, with receptor activity in the hypothalamus. GHRP can be used to increase body weight and control obesity. It has been shown to stimulate cell division and inhibit apoptosis in vitro. In vivo studies have shown that GHRP stimulates the proliferation of ester hydrochloride cells in the liver, heart, kidney, and brain. GHRP also has an anti-inflammatory effect on humans by reducing cytosolic Ca2+ levels.

Formula: C₄₆H₅₆N₁₂O₆

Purity: Min. 95%

Molecular weight: 873.01 g/mol

Ref: 3D-FG40484

GHRP-6

CAS: 87616-84-0

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₄₆H₅₆N₁₂O₆

Molecular weight: 873.01 g/mol

Ref: 3D-PP50490

Hexapeptide-2

CAS: 87616-84-0

Formula: C₅₀H₆₄N₁₂O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 929.1200

Ref: IN-DA004I2C