CAS 877399-52-5

Crizotinib

Description:

Crizotinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of non-small cell lung cancer (NSCLC) that harbor specific genetic mutations, such as ALK (anaplastic lymphoma kinase) rearrangements and ROS1 gene alterations. Its chemical formula is C21H22Cl2N4O2, and it features a complex structure that includes a bicyclic core. Crizotinib works by selectively inhibiting the activity of ALK and ROS1 kinases, thereby disrupting the signaling pathways that promote tumor growth and survival. The substance is typically administered orally and is known for its ability to penetrate the blood-brain barrier, making it effective against brain metastases. Common side effects may include nausea, diarrhea, and visual disturbances. Due to its targeted mechanism of action, crizotinib represents a significant advancement in personalized cancer therapy, allowing for more effective treatment options based on the molecular profile of the tumor. As with any medication, its use should be guided by a healthcare professional, considering potential interactions and contraindications.

Formula: C₂₁H₂₂Cl₂FN₅O

InChI: InChI=1/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

InChI key: InChIKey=KTEIFNKAUNYNJU-GFCCVEGCSA-N

SMILES: O([C@H](C)C1=C(Cl)C(F)=CC=C1Cl)C2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N

Synonyms:

• (5-(Pyridin-3-Yl)-1,3,4-Oxadiazol-2-Yl)Methanamine
• (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-ylamine
• 2-Pyridinamine, 3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy]-5-[1-(4-Piperidinyl)-1H-Pyrazol-4-Yl]-
• 3-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
• 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-Pyridinamine
• 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
• Crizotinib
• Pf 2341066
• Pf-02341066
• Pf2341066
• Xalkori
• [3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]amine
• 3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
• (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
• [3-[[(R)-1-(2,6-Dichloro-3-
• 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine
• PF-2341066/Crizotinib
• k-ras(g12c) inhibitor 6 NA
• fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]aMine
• Crozotinib
• 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-aMinopyridine
• Crizotinib (PF2341066)
• PF-02341066 Crizotinib

3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine

CAS: 877399-52-5

Formula: C₂₁H₂₂Cl₂FN₅O

Purity: 98%

Color and Shape: Solid

Molecular weight: 450.3367

Ref: IN-DA0036BC

Crizotinib

CAS: 877399-52-5

Crizotinib

Purity: ≥98%

Molecular weight: 450.34g/mol

Ref: 54-BUP15747

Crizotinib

CAS: 877399-52-5

Formula: C₂₁H₂₂Cl₂FN₅O

Color and Shape: White To Off-White Solid

Molecular weight: 450.34

Ref: 4Z-C-123001

(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

CAS: 877399-52-5

(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

Formula: C₂₁H₂₂Cl₂FN₅O

Purity: 95%

Color and Shape: white to brown solid

Molecular weight: 450.34g/mol

Ref: 54-PC402134

Crizotinib

CAS: 877399-52-5

Color and Shape: Neat

Ref: 86-MM3930.00

Crizotinib

CAS: 877399-52-5

Formula: C₂₁H₂₂Cl₂FN₅O

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 450.34

Ref: 7W-GW2561

Crizotinib

CAS: 877399-52-5

Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.

Formula: C₂₁H₂₂Cl₂FN₅O

Purity: 99% - 99.87%

Color and Shape: Solid

Molecular weight: 450.34

Ref: TM-T1661

Crizotinib

CAS: 877399-52-5

Purity: 95%

Color and Shape: Solid

Molecular weight: 450.339996337891

Ref: 10-F793129

Crizotinib

CAS: 877399-52-5

Inhibits receptor tyrosine kinases c-MET and ALK; antineoplastic

Formula: C₂₁H₂₂Cl₂FN₅O

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 450.34 g/mol

Ref: 3D-FD20585

Crizotinib - Bio-X ™

CAS: 877399-52-5

Crizotinib is a drug that belongs to the group of tyrosine kinase inhibitors. It is used in the treatment of cancers, including non-small cell lung cancer, small cell lung cancer, and other types of solid tumours. Crizotinib inhibits the activity of the tyrosine kinase ALK or anaplastic lymphoma kinase, which is involved in many signalling pathways and biological processes. The inhibition of this enzyme leads to decreased energy metabolism, reduced mitochondrial membrane potential and increased susceptibility to apoptosis.

Formula: C₂₁H₂₂Cl₂FN₅O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 450.34 g/mol

Ref: 3D-BC164334