CAS 877399-52-5
:Crizotinib
Description:
Crizotinib is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of non-small cell lung cancer (NSCLC) that harbor specific genetic mutations, such as ALK (anaplastic lymphoma kinase) rearrangements and ROS1 gene alterations. Its chemical formula is C21H22Cl2N4O2, and it features a complex structure that includes a bicyclic core. Crizotinib works by selectively inhibiting the activity of ALK and ROS1 kinases, thereby disrupting the signaling pathways that promote tumor growth and survival. The substance is typically administered orally and is known for its ability to penetrate the blood-brain barrier, making it effective against brain metastases. Common side effects may include nausea, diarrhea, and visual disturbances. Due to its targeted mechanism of action, crizotinib represents a significant advancement in personalized cancer therapy, allowing for more effective treatment options based on the molecular profile of the tumor. As with any medication, its use should be guided by a healthcare professional, considering potential interactions and contraindications.
Formula:C21H22Cl2FN5O
InChI:InChI=1/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
InChI key:InChIKey=KTEIFNKAUNYNJU-GFCCVEGCSA-N
SMILES:O([C@H](C)C1=C(Cl)C(F)=CC=C1Cl)C2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N
Synonyms:- (5-(Pyridin-3-Yl)-1,3,4-Oxadiazol-2-Yl)Methanamine
- (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-ylamine
- 2-Pyridinamine, 3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy]-5-[1-(4-Piperidinyl)-1H-Pyrazol-4-Yl]-
- 3-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
- 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-Pyridinamine
- 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
- Crizotinib
- Pf 2341066
- Pf-02341066
- Pf2341066
- Xalkori
- [3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]amine
- 3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
- (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
- [3-[[(R)-1-(2,6-Dichloro-3-
- 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine
- PF-2341066/Crizotinib
- k-ras(g12c) inhibitor 6 NA
- fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]aMine
- Crozotinib
- 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-2-aMinopyridine
- Crizotinib (PF2341066)
- PF-02341066 Crizotinib
- See more synonyms
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Found 16 products.
(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
CAS:(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amineFormula:C21H22Cl2FN5OPurity:95%Color and Shape:SolidMolecular weight:450.336683-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine
CAS:Formula:C21H22Cl2FN5OPurity:98%Color and Shape:SolidMolecular weight:450.3367Ref: IN-DA0036BC
1mg20.00€5mg24.00€10mg24.00€100mg27.00€250mg31.00€500mg46.00€1g65.00€5g178.00€10g276.00€Crizotinib (Standard)
CAS:Crizotinib (Standard) is a reference standard for research and analysis in studies involving Crizotinib. Crizotinib (PF-02341066) is a small molecule tyrosine kinase inhibitor that inhibits c-MET and ALK receptors (IC50=8/20 nM), is ATP-competitive, and also inhibits ROS1. Crizotinib exhibits antitumor activity and inhibits tumor growth.Formula:C21H22Cl2FN5OColor and Shape:SolidMolecular weight:450.34Crizotinib
CAS:Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Formula:C21H22Cl2FN5OPurity:99% - 99.87%Color and Shape:White SolidMolecular weight:450.34Crizotinib
CAS:Formula:C21H22Cl2FN5OPurity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:450.34Crizotinib
CAS:(R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amineFormula:C21H22Cl2FN5OPurity:98%Molecular weight:450.34Crizotinib
CAS:Inhibits receptor tyrosine kinases c-MET and ALK; antineoplasticFormula:C21H22Cl2FN5OPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:450.34 g/molCrizotinib - Bio-X ™
CAS:Crizotinib is a drug that belongs to the group of tyrosine kinase inhibitors. It is used in the treatment of cancers, including non-small cell lung cancer, small cell lung cancer, and other types of solid tumours. Crizotinib inhibits the activity of the tyrosine kinase ALK or anaplastic lymphoma kinase, which is involved in many signalling pathways and biological processes. The inhibition of this enzyme leads to decreased energy metabolism, reduced mitochondrial membrane potential and increased susceptibility to apoptosis.
Formula:C21H22Cl2FN5OPurity:Min. 95%Color and Shape:PowderMolecular weight:450.34 g/mol
![3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine](https://static.cymitquimica.com/products/IN/thumb/DA0036BC.jpg)
