CAS 87760-53-0

Tandospirone

Description:

Tandospirone is an anxiolytic medication primarily used in the treatment of anxiety disorders. It belongs to the class of drugs known as azapirones, which are characterized by their unique chemical structure that includes a bicyclic system. The substance acts as a selective serotonin receptor agonist, particularly targeting the 5-HT1A receptor, which plays a crucial role in the modulation of mood and anxiety. Tandospirone is known for its relatively low side effect profile compared to traditional benzodiazepines, making it a preferred option for long-term management of anxiety. It is typically administered orally and has a moderate onset of action. The pharmacokinetics of tandospirone indicate that it is well-absorbed, with a bioavailability that allows for effective therapeutic levels. Additionally, it has a favorable safety profile, with minimal risk of dependence or withdrawal symptoms, which is a significant advantage over other anxiolytics. Overall, tandospirone represents a valuable option in the pharmacological management of anxiety disorders.

Formula: C₂₁H₂₉N₅O₂

InChI: InChI=1/C21H29N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3,6-7,15-18H,1-2,4-5,8-14H2/t15-,16+,17+,18-

InChI key: InChIKey=CEIJFEGBUDEYSX-FZDBZEDMNA-N

SMILES: O=C1[C@]2([C@]([C@]3(C[C@@]2(CC3)[H])[H])(C(=O)N1CCCCN4CCN(CC4)C=5N=CC=CN5)[H])[H]

Synonyms:

• (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3-bicyclo[2.2.1]heptanedicarboximide
• (1R,2S,6R,7S)-4-{4-[4-(Pyrimidin-2-yl)piperazin-1-yl]butyl}-4-azatricyclo[5.2.1.0~2,6~]decane-3,5-dione
• (3aR,4S,7R,7aS)-2-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
• (3aa,4b,7b,7aa)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione
• 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-
• 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aα,4β,7β,7aα)-
• 4,7-methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-
• rel-(3aR,4S,7R,7aS)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione
• Tandospirone

4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aα,4β,7β,7aα)-

CAS: 87760-53-0

Formula: C₂₁H₂₉N₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 383.4873

Ref: IN-DA0036C9

Tandospirone

CAS: 87760-53-0

Formula: C₂₁H₂₉N₅O₂

Molecular weight: 383.49

Ref: 7W-GP5686

Tandospirone

CAS: 87760-53-0

Tandospirone

Purity: ≥98%

Molecular weight: 383.49g/mol

Ref: 54-BUP12642

Tandospirone

CAS: 87760-53-0

Formula: C₂₁H₂₉N₅O₂

Color and Shape: White To Off-White Solid

Molecular weight: 383.50

Ref: 4Z-T-212001

Tandospirone

CAS: 87760-53-0

Tandospirone (SM-3997) is a 5-HT1A receptor partial agonist with anxiolytic and antidepressant activity used in the study of central nervous system disorders.

Formula: C₂₁H₂₉N₅O₂

Purity: 99.94%

Color and Shape: Solid

Molecular weight: 383.49

Ref: TM-TQ0315

Tandospirone

Controlled Product

CAS: 87760-53-0

Applications Tandospirone is a 5HT1A receptor partial agonist. Studies indicate that tandospirone significantly reduces haloperidol-induced bradykinesia in a dose dependent manner. The potency of Tandospirone is equal to that of buspirone and approximate one-half that of diazepam. The potency of Tandospirone at dopamine antagonistic action is less than 1/4 that of buspirone.
References Seymour, P.A., et al.: Prog. Clin. Biol. Res., 361, 453 (1990), Evans, S.M., et al.: J. Pharmacol. Exp. Ther., 271, 683 (1994),

Formula: C₂₁H₂₉N₅O₂

Color and Shape: Neat

Molecular weight: 383.49

Ref: TR-T006430

Tandospirone

CAS: 87760-53-0

Tandospirone is a psychotropic drug that acts as a selective serotonin receptor partial agonist. It is derived from a synthetic source, specifically targeting the 5-HT1A receptors in the brain. Tandospirone modulates serotonergic neurotransmission by binding to these receptors, which are associated with mood regulation. This action results in the anxiolytic and antidepressant effects observed with the drug.

Formula: C₂₁H₂₉N₅O₂

Purity: Min. 95%

Molecular weight: 383.49 g/mol

Ref: 3D-FT28000

Tandospirone hydrochloride

CAS: 87760-53-0

Tandospirone hydrochloride is a drug that affects the serotonin receptor 5-HT1A. It has been shown to have a number of clinical properties, including the treatment of anxiety, depression and irritable bowel syndrome. Tandospirone has been shown to be effective in combination with sodium carbonate for the treatment of high-resistant symptoms. This drug inhibits dopamine uptake and increases locomotor activity by blocking D2 receptors in the brain. Tandospirone also has pharmacological effects on 5-HT1 receptors, which are involved in regulating mood and sleep cycles.

Formula: C₂₁H₂₉N₅O₂·HCl

Purity: Min. 95%

Molecular weight: 419.95 g/mol

Ref: 3D-FT31558