CAS 87802-11-7

methyl 5-chloro-1H-indole-2-carboxylate

Description:

Methyl 5-chloro-1H-indole-2-carboxylate is a chemical compound characterized by its indole structure, which is a bicyclic compound consisting of a benzene ring fused to a pyrrole ring. The presence of a chloro group at the 5-position and a carboxylate ester at the 2-position contributes to its unique reactivity and properties. This compound typically appears as a solid or liquid, depending on the specific conditions, and is often used in organic synthesis and medicinal chemistry due to its potential biological activity. It may exhibit properties such as moderate solubility in organic solvents and limited solubility in water, which is common for many indole derivatives. The chloro substituent can influence the compound's reactivity, making it a useful intermediate in the synthesis of more complex molecules. Safety precautions should be taken when handling this compound, as it may pose health risks if ingested or inhaled. Overall, methyl 5-chloro-1H-indole-2-carboxylate is a valuable compound in the field of organic chemistry.

Formula: C₁₀H₈ClNO₂

InChI: InChI=1/C10H8ClNO2/c1-14-10(13)9-5-6-4-7(11)2-3-8(6)12-9/h2-5,12H,1H3

InChI key: WGAOEHZSJWVLBY-UHFFFAOYSA-N

SMILES: COC(=O)c1cc2cc(ccc2[nH]1)Cl

Synonyms:

• 1H-indole-2-carboxylic acid, 5-chloro-, methyl ester
• Methyl 5-chloro-1H-indole-2-carboxylate

5-Chloro-1H-Indole-2-Carboxylic Acid Methyl Ester

CAS: 87802-11-7

5-Chloro-1H-Indole-2-Carboxylic Acid Methyl Ester

Formula: C₁₀H₈ClNO₂

Purity: 0.97

Color and Shape: Solid

Molecular weight: 209.63

Ref: 54-OR1011846

Methyl 5-chloro-1H-indole-2-carboxylate

CAS: 87802-11-7

Formula: C₁₀H₈ClNO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 209.6290

Ref: IN-DA004K59

Methyl 5-chloro-1H-indole-2-carboxylate

CAS: 87802-11-7

Methyl 5-chloro-1H-indole-2-carboxylate

Formula: C₁₀H₈ClNO₂

Purity: 98%

Molecular weight: 209.63

Ref: IN-DG103232

5-Chloroindole-2-carboxylic acid methyl ester

CAS: 87802-11-7

5-Chloroindole-2-carboxylic acid methyl ester is a potent inhibitor of the enzyme tyrosine kinase in cell culture, with an IC50 value of 0.5 nM. It has been shown to inhibit the growth of cancer cells (e.g., MDA-MB231, MCF-7) in vitro and in vivo. The IC50 values for inhibition of MDA-MB231 and MCF-7 cells are 0.1 and 10 nM, respectively. 5-Chloroindole-2-carboxylic acid methyl ester binds to the ATP binding site on tyrosine kinase, preventing ATP from binding and inhibiting phosphorylation of the receptor protein. This allows the receptor's downstream signaling pathways to be blocked, which leads to cell growth inhibition by arresting cell cycle progression at G0/G1 phase or inducing apoptosis.

Formula: C₁₀H₈ClNO₂

Purity: Min. 95%

Molecular weight: 209.63 g/mol

Ref: 3D-FC56771

Methyl 5-chloro-1H-indole-2-carboxylate

CAS: 87802-11-7

Formula: C₁₀H₈ClNO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 209.63

Ref: 10-F225765