CAS 87828-86-2

L-leucine-5,5,5-D3

Description:

L-leucine-5,5,5-D3 is a stable isotope-labeled form of the essential amino acid L-leucine, which is crucial for protein synthesis and various metabolic processes in the body. The "5,5,5-D3" designation indicates that three deuterium atoms (heavy hydrogen isotopes) are incorporated at the fifth carbon position of the leucine molecule, allowing for its use in metabolic studies and tracer experiments. This compound retains the fundamental characteristics of L-leucine, including its hydrophobic nature and role in promoting muscle protein synthesis. It is typically used in research settings, particularly in studies involving amino acid metabolism, protein turnover, and nutritional assessments. The presence of deuterium enhances the compound's stability and allows for precise tracking in biochemical pathways. L-leucine itself is known for its branched-chain structure, which contributes to its unique properties and functions in biological systems. As with many isotopically labeled compounds, L-leucine-5,5,5-D3 is handled with care in laboratory settings to ensure accurate experimental results.

Formula: C6H13NO2

InChI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1/i1D3/t4?,5-

InChI key: ROHFNLRQFUQHCH-LONBSJBQSA-N

SMILES: [2H]C([2H])([2H])C(C)C[C@@H](C(=O)O)N

L-Leucine-D3

CAS: 87828-86-2

L-Leucine-D3

Formula: C₆H₁₀D₃NO₂

Purity: 98%

Molecular weight: 134.19

Ref: 54-DE2034

L-Leucine-d3 (methyl-d3)

CAS: 61-90-5, 87828-86-2

Formula: CH₃CH(CD₃)CH₂CH(NH₂)COOH

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 134.11346

Ref: 3U-D1973

L-Leucine-d3

Controlled Product

CAS: 87828-86-2

Applications Labelled L-Leucine used as tracers to study human apolipoprotein B metabolism. L-Leucine is an essential amino acid. L-Leucine acts as a nutrient signal to stimulate protein synthesis. It has also activates the mammalian target of rapamycin kinase that regulates cell growth.
References Demant, T. et al.: Am. J. Physiol., 270, E1022 (1996); Diraison, F. et al.: Am. J. Physiol., 277, E529 (1999); Suryawan, A. et al.: J. Anim. Sci., 89, 2004 (2011); Peyrollier, K. et al.: Biochem. J., 350, 361 (2000);

Formula: C₆₂H₃H₁₀NO₂

Color and Shape: Neat

Molecular weight: 134.19

Ref: TR-L330112

L-Leucine-d3 (methyl-d3)

CAS: 87828-86-2

Formula: C₆H₁₀D₃NO₂

Molecular weight: 134.19

Ref: 4Z-L-117030

L-Leucine-5,5,5-d3

Controlled Product

CAS: 87828-86-2

L-Leucine-5,5,5-d3 is a stable isotope of leucine with three deuterium atoms. It is used in metabolic studies to detect the rate of protein synthesis in vivo and to study the roles of leucine in disease activity. It has been shown that L-leucine-5,5,5-d3 can be used as a tracer for the measurement of kinetic parameters in human serum. The linear calibration curve for L-leucine-5,5,5-d3 is based on its use as an internal standard for LC/MS/MS methods that measure cholesterol synthesis and receptor activity.

Formula: C₆H₁₀D₃NO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 134.19 g/mol

Ref: 3D-MDA82886

L-Leucine-d3 (methyl-d3)

CAS: 87828-86-2

Formula: C₆H₁₃NO₂

Molecular weight: 134.19

Ref: BE-MD-4415D3