CAS 87862-25-7

m-iodo-benzylguanidine sulfate

Description:

m-Iodo-benzylguanidine sulfate, commonly referred to as MIBG, is a chemical compound that serves primarily as a radiopharmaceutical and is utilized in medical imaging and treatment, particularly in neuroendocrine tumors. It is characterized by its structure, which includes a benzyl group substituted with an iodine atom at the meta position relative to the guanidine moiety. This substitution enhances its affinity for certain receptors, particularly the norepinephrine transporter, making it useful in targeting neuroblastoma and other tumors that express these receptors. The sulfate component contributes to its solubility in aqueous solutions, facilitating its use in clinical settings. MIBG is typically administered in a radiolabeled form, allowing for both diagnostic imaging via scintigraphy and therapeutic applications through targeted radiation. Safety and efficacy are paramount in its use, necessitating careful handling and administration by healthcare professionals. Overall, m-iodo-benzylguanidine sulfate is a significant compound in the field of nuclear medicine, combining unique chemical properties with practical applications in oncology.

Synonyms:

• (3-Iodobenzyl)guanidine hemisulfate
• MIBG hemisulfate
• meta-Iodobenzylguanidine hemisulfate
• Guanidine, [(3-iodophenyl)methyl]-, sulfate (2:1)

IOBENGUANE SULFATE CRS

CAS: 87862-25-7

IOBENGUANE SULFATE CRS

Formula: C₈H₁₂IN₃O₄S

Molecular weight: 373.1681

Ref: 41-I0328000

Iobenguane sulfate

CAS: 87862-25-7

Iobenguane sulfate is used in radioiodinated form to diagnose and treat adrenergic tumors.

Formula: C₈H₁₀IN₃H₂O₄S

Purity: 99.04%

Color and Shape: Solid

Molecular weight: 324.12

Ref: TM-T15588

Guanidine, [(3-iodophenyl)methyl]-, sulfate (2:1)

CAS: 87862-25-7

Formula: C₁₆H₂₂I₂N₆O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 648.2576

Ref: IN-DA004J6J

Iobenguane sulfate

CAS: 87862-25-7

Iobenguane sulfate

Purity: ≥98%

Molecular weight: 324.12g/mol

Ref: 54-BUP10326

3-Iodobenzylguanidine hemisulphate [m-IBG]

CAS: 87862-25-7

3-Iodobenzylguanidine hemisulphate [m-IBG]

Purity: 97%

Molecular weight: 648.26g/mol

Ref: 54-OR0884

Iobenguane Hemisulfate

CAS: 87862-25-7

Formula: C₈H₁₀IN₃₁H₂SO₄

Molecular weight: 275.09 49.03

Ref: 4Z-I-110001

m-Iodobenzylguanidine Hemisulfate

Controlled Product

CAS: 87862-25-7

Formula: C₈H₁₀IN₃·H₂O₄S

Color and Shape: Neat

Molecular weight: 648.26

Ref: TR-I693700

m-Iodobenzylguanidine hemisulfate

CAS: 87862-25-7

m-Iodobenzylguanidine hemisulfate (MBG) is an anti-cancer compound that inhibits the uptake of fatty acids by the mitochondria, leading to cell death. MBG has been shown to have a high affinity for cardiac fatty acid binding protein and low affinity for human serum albumin. MBG has been used in the diagnosis and treatment of infectious diseases, autoimmune diseases, and as a radiation sensitizer. MBG is also used in diagnostic radiology as a contrast agent for myocardial perfusion imaging. The uptake of MBG is dependent on the presence of specific receptors, which are located on the cell membrane. These receptors are called carboxy terminal (CT). It has been shown that CT-1 is involved in the uptake of MBG into cells and that CT-2 may be involved in its metabolism.

Formula: C₈H₁₀IN₃H₂SO₄

Purity: Min. 95%

Ref: 3D-FI178147