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CAS 87862-25-7

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m-iodo-benzylguanidine sulfate

Description:
m-Iodo-benzylguanidine sulfate, commonly referred to as MIBG, is a chemical compound that serves primarily as a radiopharmaceutical and is utilized in medical imaging and treatment, particularly in neuroendocrine tumors. It is characterized by its structure, which includes a benzyl group substituted with an iodine atom at the meta position relative to the guanidine moiety. This substitution enhances its affinity for certain receptors, particularly the norepinephrine transporter, making it useful in targeting neuroblastoma and other tumors that express these receptors. The sulfate component contributes to its solubility in aqueous solutions, facilitating its use in clinical settings. MIBG is typically administered in a radiolabeled form, allowing for both diagnostic imaging via scintigraphy and therapeutic applications through targeted radiation. Safety and efficacy are paramount in its use, necessitating careful handling and administration by healthcare professionals. Overall, m-iodo-benzylguanidine sulfate is a significant compound in the field of nuclear medicine, combining unique chemical properties with practical applications in oncology.
Formula:C16H22I2N6O4S
InChI:InChI=1S/2C8H10IN3.H2O4S/c2*9-7-3-1-2-6(4-7)5-12-8(10)11;1-5(2,3)4/h2*1-4H,5H2,(H4,10,11,12);(H2,1,2,3,4)
InChI key:XNACDNPGABUBFR-UHFFFAOYSA-N
SMILES:C1=CC(=CC(=C1)I)CN=C(N)N.C1=CC(=CC(=C1)I)CN=C(N)N.OS(=O)(=O)O
Synonyms:
  • (3-Iodobenzyl)guanidine hemisulfate
  • MIBG hemisulfate
  • meta-Iodobenzylguanidine hemisulfate
  • Guanidine, [(3-iodophenyl)methyl]-, sulfate (2:1)
Found 10 products.