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CAS 882-09-7

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Clofibric acid

Description:
Clofibric acid is a pharmaceutical compound primarily used as a lipid-regulating agent, particularly for lowering cholesterol and triglyceride levels in the blood. It belongs to the class of drugs known as fibrates, which function by activating peroxisome proliferator-activated receptors (PPARs) to enhance lipid metabolism. The chemical formula of clofibric acid is C12H12ClO3, and it features a chlorophenyl group, a carboxylic acid functional group, and an ethyl side chain. Clofibric acid is typically presented as a white to off-white crystalline powder, and it is sparingly soluble in water but more soluble in organic solvents. Its pharmacological effects include the reduction of atherosclerosis risk and improvement of lipid profiles, making it beneficial for patients with dyslipidemia. However, its use has declined due to the availability of newer agents with improved efficacy and safety profiles. Clofibric acid is also notable for its environmental persistence, as it has been detected in wastewater and aquatic environments, raising concerns about its ecological impact.
Formula:C10H11ClO3
InChI:InChI=1S/C10H11ClO3/c1-10(2,9(12)13)14-8-5-3-7(11)4-6-8/h3-6H,1-2H3,(H,12,13)
InChI key:InChIKey=TXCGAZHTZHNUAI-UHFFFAOYSA-N
SMILES:O(C(C(O)=O)(C)C)C1=CC=C(Cl)C=C1
Synonyms:
  • (p-Chlorophenoxy)isobutyric acid
  • 2-(4-Chlorophenoxy)-2-Methylpropanoate
  • 2-(4-Chlorophenoxy)-2-Methylpropanoic Acid
  • 2-(4-Chlorophenoxy)-2-methylpropanic acid
  • 2-(4-Chlorophenoxy)-2-methylpropionic acid
  • 2-(4-Chlorophenoxy)isobutyric acid
  • 2-(p-Chlorophenoxy)-2-methylpropanoic acid
  • 2-(p-Chlorophenoxy)-2-methylpropionic acid
  • 2-(p-Chlorophenoxy)isobutyric acid
  • 2-(p-Chlorphenoxy)-2-methylpropionsaure
  • See more synonyms
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