CAS 88321-09-9

Loxistatin

Description:

Loxistatin, with the CAS number 88321-09-9, is a synthetic compound primarily known for its role as a potent inhibitor of the enzyme HMG-CoA reductase, which is crucial in the cholesterol biosynthesis pathway. This characteristic positions Loxistatin as a potential therapeutic agent in managing hyperlipidemia and related cardiovascular conditions. The compound exhibits a specific chemical structure that contributes to its biological activity, typically characterized by a lactone ring and various functional groups that enhance its interaction with the target enzyme. Loxistatin has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, which are essential for understanding its efficacy and safety profile. Additionally, like other statins, it may have pleiotropic effects, potentially influencing inflammation and endothelial function. However, as with any pharmaceutical agent, the use of Loxistatin may be associated with side effects, necessitating careful consideration in clinical applications. Further research continues to explore its full therapeutic potential and mechanisms of action.

Formula: C₁₇H₃₀N₂O₅

InChI: InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1

InChI key: InChIKey=SRVFFFJZQVENJC-IHRRRGAJSA-N

SMILES: C(N[C@H](C(NCCC(C)C)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(OCC)=O)O1

Synonyms:

• 2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
• Aloxistatin
• E 64c ethyl ester
• E-64d
• E64d
• E64d/pepstatin
• EST
• EST (pharmaceutical)
• Ep 453
• Loxistatin
• NSC 694281
• Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-
• Oxiranecarboxylic acid, 3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, [2S-[2α,3β(R*)]]-
• Pepstatin E64d
• ethyl (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylate

L-trans-Epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester

CAS: 88321-09-9

E64d (EST), a membrane permeable analog of E64c, was expected to be useful as an oral drug for muscular dystrophy due to its potent inhibitory activities against the cysteine proteinases involved in the myofibrillar protein degradation that occurs in this disease. E64d attenuates the effects of parathyroid hormone on osteoblasts in vitro. By inhibiting cathepsin B, a cysteine protease showing β-secretase activity, E64d could reduce brain Aβ and improve memory deficits in Alzheimer’s disease animal models.

Formula: C₁₇H₃₀N₂O₅

Purity: > 99%

Color and Shape: White

Molecular weight: 342.44

Ref: 01-4027911

2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-

CAS: 88321-09-9

Formula: C₁₇H₃₀N₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 342.4305

Ref: IN-DA0048C1

Aloxistatin

CAS: 88321-09-9

Aloxistatin

Purity: ≥98%

Molecular weight: 342.43g/mol

Ref: 54-BUP15070

E-64d [for Biochemical Research]

CAS: 88321-09-9

Formula: C₁₇H₃₀N₂O₅

Purity: >95.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 342.44

Ref: 3B-E1337

E-64d protease inhibitor

CAS: 88321-09-9

Formula: C₁₇H₃₀N₂O₅

Purity: ≥ 95.0%

Color and Shape: White powder

Molecular weight: 342.43

Ref: 7W-GL9790

E-64d

CAS: 88321-09-9

E-64d

Formula: C₁₇H₃₀N₂O₅

Purity: 98.8% (hplc) (Typical Value in Batch COA)

Color and Shape: Powder

Molecular weight: 342.43g/mol

Ref: 54-BIE1005

Aloxistatin

CAS: 88321-09-9

Aloxistatin (E64d) inhibits cysteine proteases, blocks calpain in platelets, and prevents blood clotting.

Formula: C₁₇H₃₀N₂O₅

Purity: 99.46% - 99.69%

Color and Shape: Solid

Molecular weight: 342.43

Ref: TM-T6040

E-64d

Controlled Product

CAS: 88321-09-9

Applications E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.
References Wilcox, D. et al.: Biochem. J., 285, 495 (1992); McGowan, E.B. et al.: Biochem. Biophys. Res. Comm., 158, 432 (1989); Tsubokawa, T. et al.: J. Neurosci. Res., 84, 832 (2006);

Formula: C₁₇H₃₀N₂O₅

Color and Shape: Neat

Molecular weight: 342.43

Ref: TR-E100500

(2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester

CAS: 88321-09-9

Inhibitor of cathepsins

Formula: C₁₇H₃₀N₂O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 342.43 g/mol

Ref: 3D-FE29623

E-64-d

CAS: 88321-09-9

E-64-d is a research tool that is used in cell biology, pharmacology, and biochemistry to study protein interactions. E-64-d is an activator, ligand, or receptor for ion channels and has been shown to inhibit the activity of high purity K+ channels. This peptide binds to the extracellular loop of voltage-gated potassium channels (Kv1.2) and inhibits the opening of these channels by blocking their access to ATP. E-64-d also binds to an antibody as a competitive inhibitor of the antigen binding site on the antibody.

Formula: C₁₇H₃₀N₂O₅

Purity: Min. 95%

Molecular weight: 342.43 g/mol

Ref: 3D-IED-4321-V

L-TRANS-EPOXYSUCCINYL-LEU-3-METHYLBUTYLAMIDE-ETHYL ESTER

CAS: 88321-09-9

Purity: 95.0%

Molecular weight: 342.4360046386719

Ref: 10-F475468