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CAS 88495-63-0

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Artesunate

Description:
Artesunate is a semi-synthetic derivative of artemisinin, which is extracted from the sweet wormwood plant, Artemisia annua. It is primarily used as an antimalarial medication, particularly effective against Plasmodium falciparum, the parasite responsible for the most severe form of malaria. Artesunate is known for its rapid action and is often administered intravenously or intramuscularly in severe cases. The compound has a molecular formula that includes carbon, hydrogen, and oxygen, reflecting its organic nature. Artesunate exhibits a unique mechanism of action, generating reactive oxygen species that damage the malaria parasite's cellular components. It is generally well-tolerated, though potential side effects can include gastrointestinal disturbances and allergic reactions. Artesunate is often used in combination therapies to enhance efficacy and reduce the risk of resistance development. Its stability and solubility in water make it suitable for various formulations, contributing to its widespread use in malaria treatment protocols globally.
Formula:C19H28O8
InChI:InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1
InChI key:InChIKey=FIHJKUPKCHIPAT-AHIGJZGOSA-N
SMILES:C[C@@H]1[C@]2([C@]34[C@](O[C@H]1OC(CCC(O)=O)=O)(O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])[H])[H]
Synonyms:
  • (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol hydrogen succinate
  • 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, butanedioic acid deriv.
  • 4-oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid
  • 4-oxo-4-{[(5aS,6R,8aS,9R,10R,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid
  • Arinate
  • Armax 200
  • Arsuamoon
  • Arsumax
  • Arteannuinum
  • Arteannuinum succinate
  • See more synonyms
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