CAS 886993-02-8

L-Prolinamide, N-acetylglycyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-

Description:

L-Prolinamide, N-acetylglycyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]- is a synthetic organic compound characterized by its complex structure, which includes a prolinamide moiety and a benzopyran derivative. The presence of the trifluoromethyl group enhances its lipophilicity and may influence its biological activity. This compound is likely to exhibit specific interactions due to its functional groups, which can participate in hydrogen bonding and other intermolecular forces. The benzopyran structure suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals, as benzopyrans are known for their diverse biological activities, including anti-inflammatory and antioxidant properties. Additionally, the acetyl and glycine components may contribute to its solubility and stability in various solvents. Overall, L-Prolinamide, N-acetylglycyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]- represents a compound of interest for further research in drug development and chemical synthesis.

Formula: C₁₉H₁₈F₃N₃O₅

InChI: InChI=1S/C19H18F3N3O5/c1-10(26)23-9-16(27)25-6-2-3-14(25)18(29)24-11-4-5-12-13(19(20,21)22)8-17(28)30-15(12)7-11/h4-5,7-8,14H,2-3,6,9H2,1H3,(H,23,26)(H,24,29)/t14-/m0/s1

InChI key: InChIKey=SKKLIRUAUNZTRY-AWEZNQCLSA-N

SMILES: C(F)(F)(F)C=1C=2C(=CC(NC(=O)[C@H]3N(C(CNC(C)=O)=O)CCC3)=CC2)OC(=O)C1

Synonyms:

• L-Prolinamide, N-acetylglycyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-
• (S)-1-(2-Acetamidoacetyl)-N-(2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl)pyrrolidine-2-carboxamide

Ac-Gly-Pro-AFC

CAS: 886993-02-8

Ac-GP-AFC, specific substrate for the endopeptidase activity of fibroblast activation protein (FAP) (Km = 330 ± 30 μM; kcat = 7.7 ± 0.2 s⁻ ¹).

Formula: C₁₉H₁₈F₃N₃O₅

Purity: 99.5%

Color and Shape: Light Yellow Powder

Molecular weight: 425.36

Ref: 01-4053025

Ac-Gly-Pro-AFC

CAS: 886993-02-8

Ac-Gly-Pro-AFC is a dipeptidyl peptidase inhibitor that inhibits the action of protein-degrading enzymes called peptidases. Ac-Gly-Pro-AFC has been shown to be effective in treating diabetes by inhibiting the activity of fibroblast activation protein, which is involved in the development of diabetes. Ac-Gly-Pro-AFC also has an inhibitory effect on the enzyme connect, which is involved in cellular proliferation and differentiation. Clinical trials have been conducted to evaluate the efficacy of this drug for treatment of diabetic nephropathy with promising results. Ac-Gly-Pro-AFC has also been shown to have a beneficial effect on collagen synthesis and inhibition of proinflammatory cytokine release from activated macrophages.

Formula: C₁₉H₁₈F₃N₃O₅

Purity: Min. 95%

Molecular weight: 425.36 g/mol

Ref: 3D-FA110612