CAS 89226-50-6: Manidipine

Description: Manidipine is a calcium channel blocker primarily used in the treatment of hypertension and certain cardiovascular conditions. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac cells, leading to vasodilation and reduced blood pressure. Manidipine is characterized by its high selectivity for vascular calcium channels, which minimizes effects on cardiac contractility. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its chemical structure includes a dihydropyridine ring, which is essential for its pharmacological activity. Manidipine is known for its favorable side effect profile, with a lower incidence of reflex tachycardia compared to some other calcium channel blockers. Additionally, it may have beneficial effects on renal function, making it a suitable option for patients with hypertension and renal impairment. As with any medication, it is important to consider potential interactions and contraindications when prescribing Manidipine.

Formula: C₃₅H₃₈N₄O₆

InChI: InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3

InChI key: InChIKey=ANEBWFXPVPTEET-UHFFFAOYSA-N

SMILES: O=C(OC)C1=C(NC(=C(C(=O)OCCN2CCN(CC2)C(C=3C=CC=CC3)C=4C=CC=CC4)C1C=5C=CC=C(C5)N(=O)=O)C)C

Synonyms:

• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester
• 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-[2-(4-benzhydryl-piperazin-1-yl)-ethyl] ester 5-methyl ester
• 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 2-[4-(Diphenylmethyl)-1-piperazinyl]ethylmethyl (±)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylate
• 2-[4-(Diphenylmethyl)Piperazin-1-Yl]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate
• 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, 2-[4-(Diphenylmethyl)-1-Piperazinyl]Ethyl Methyl Ester
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester
• 5-({2-[4-(Diphenylmethyl)Piperazin-1-Yl]Ethoxy}Carbonyl)-1,2,6-Trimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3-Carboxylate
• Franidipine
• Manidipine 6300
• Manidipine
• (±)-Manidipine

Manidipine Dihydrochloride

CAS: 89226-50-689226-75-5

• Formula: C₃₅H₃₈N₄O₆·2HCl
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 683.63

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester

CAS: 89226-50-6

• Formula: C₃₅H₃₈N₄O₆
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 610.6994

Manidipine

CAS: 89226-50-6

• Purity: ≥98%
• Molecular weight: 610.7g/mol

3-(2-(4-Benzhydrylpiperazin-1-Yl)Ethyl) 5-Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate

CAS: 89226-50-6

• Purity: 98%
• Molecular weight: 610.7g/mol

Manidipine

CAS: 89226-50-6

• Formula: C₃₅H₃₈N₄O₆
• Color and Shape: Pale Yellow Solid
• Molecular weight: 610.71

Manidipine

CAS: 89226-50-6

Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized

• Formula: C₃₅H₃₈N₄O₆
• Purity: 99.30%
• Color and Shape: Solid
• Molecular weight: 610.7

Manidipine

CAS: 89226-50-6

Applications A dihydropyridine calcium channel blocker. Antihypertensive. References Meguro, K., et al.: Chem. Pharm. Bull., …

• Formula: C₃₅H₃₈N₄O₆
• Color and Shape: Off White Powder
• Molecular weight: 610.70

Manidipine

CAS: 89226-50-6

Manidipine is a dinucleotide phosphate that binds to the enzyme phosphodiesterase, inhibiting the breakdown of …

• Formula: C₃₅H₃₈N₄O₆
• Purity: Min. 95%
• Molecular weight: 610.7 g/mol