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CAS 89226-75-5

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Manidipine dihydrochloride

Description:
Manidipine dihydrochloride is a calcium channel blocker primarily used in the treatment of hypertension and certain cardiovascular conditions. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. The substance is characterized by its dihydrochloride salt form, which enhances its solubility and bioavailability. Manidipine exhibits a long half-life, allowing for once-daily dosing, which improves patient compliance. Its pharmacological profile includes not only antihypertensive effects but also potential benefits in reducing myocardial oxygen demand. The compound is typically administered orally and may be associated with side effects such as peripheral edema, headache, and flushing. As with any medication, it is essential to consider contraindications and interactions with other drugs. Overall, Manidipine dihydrochloride is a valuable therapeutic agent in managing high blood pressure and related cardiovascular issues.
Formula:C35H40Cl2N4O6
InChI:InChI=1/C35H38N4O6.ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27;/h4-16,23,32-33,36H,17-22H2,1-3H3;1H
InChI key:InChIKey=JINNGBXKBDUGQT-UHFFFAOYSA-N
SMILES:C(OCCN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)(=O)C=4C(C(C(OC)=O)=C(C)NC4C)C5=CC(N(=O)=O)=CC=C5.Cl
Synonyms:
  • 2-(4-Benzhydrylpiperazin-1-yl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
  • 2-[4-(Diphenylmethyl)Piperazin-1-Yl]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Hydrochloride
  • 2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
  • 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, 2-[4-(Diphenylmethyl)-1-Piperazinyl]Ethyl Methyl Ester, Hydrochloride (1:2)
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester, hydrochloride (1:2)
  • Calslot
  • Cv 4093
  • Franidipine hydrochloride
  • Manidipine hydrochloride
  • See more synonyms
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Found 12 products.