CAS 89226-75-5

Manidipine dihydrochloride

Description:

Manidipine dihydrochloride is a calcium channel blocker primarily used in the treatment of hypertension and certain cardiovascular conditions. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue, leading to vasodilation and reduced blood pressure. The substance is characterized by its dihydrochloride salt form, which enhances its solubility and bioavailability. Manidipine exhibits a long half-life, allowing for once-daily dosing, which improves patient compliance. Its pharmacological profile includes not only antihypertensive effects but also potential benefits in reducing myocardial oxygen demand. The compound is typically administered orally and may be associated with side effects such as peripheral edema, headache, and flushing. As with any medication, it is essential to consider contraindications and interactions with other drugs. Overall, Manidipine dihydrochloride is a valuable therapeutic agent in managing high blood pressure and related cardiovascular issues.

Formula: C₃₅H₄₀Cl₂N₄O₆

InChI: InChI=1/C35H38N4O6.ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27;/h4-16,23,32-33,36H,17-22H2,1-3H3;1H

InChI key: InChIKey=JINNGBXKBDUGQT-UHFFFAOYSA-N

SMILES: C(OCCN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)(=O)C=4C(C(C(OC)=O)=C(C)NC4C)C5=CC(N(=O)=O)=CC=C5.Cl

Synonyms:

• 2-(4-Benzhydrylpiperazin-1-yl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
• 2-[4-(Diphenylmethyl)Piperazin-1-Yl]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate Hydrochloride
• 2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
• 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,6-Dimethyl-4-(3-Nitrophenyl)-, 2-[4-(Diphenylmethyl)-1-Piperazinyl]Ethyl Methyl Ester, Hydrochloride (1:2)
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester, hydrochloride (1:2)
• Calslot
• Cv 4093
• Franidipine hydrochloride
• Manidipine hydrochloride
• (±)-Manidipine dihydrochloride
• 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
• 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, dihydrochloride (9CI)
• CV-4093(2HCl)
• 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester hydrochloride
• franidipinehydrochloride
• cv-4093dihydrochlorde

Manidipine Dihydrochloride

CAS: 89226-50-6, 89226-75-5

Formula: C₃₅H₃₈N₄O₆·2HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 683.63

Ref: 3B-M2225

Manidipine dihydrochloride

CAS: 89226-75-5

Calcium channel blocker

Formula: C₃₅H₃₈N₄O₆•2HCl

Molecular weight: 683.63

Ref: 02-J60496

Manidipine DiHCl

CAS: 89226-75-5

Formula: C₃₅H₃₈Cl₂N₄O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 683.6213

Ref: IN-DA0043GI

Manidipine dihydrochloride

CAS: 89226-75-5

Manidipine dihydrochloride (Manidipine 2HCl) is a potent calcium channel blocker for Ca2+ current(IC50=2.6 nM).

Formula: C₃₅H₄₀Cl₂N₄O₆

Purity: 99.76% - 99.86%

Color and Shape: Solid

Molecular weight: 683.62

Ref: TM-T0193

Manidipine Dihydrochloride

CAS: 89226-75-5

Manidipine Dihydrochloride

Purity: 99%

Molecular weight: 683.62g/mol

Ref: 54-OR1013718

Manidipine DiHCl

CAS: 89226-75-5

Formula: C₃₅H₃₈N₄O₆·2HCl

Color and Shape: Off-White Solid

Molecular weight: 610.71 2*36.46

Ref: 4Z-M-2610

Manidipine dihydrochloride

CAS: 89226-75-5

Manidipine dihydrochloride

Purity: ≥98%

Molecular weight: 683.62g/mol

Ref: 54-BUP14828

Manidipine dihydrochloride

CAS: 89226-75-5

Formula: C₃₅H₃₈N₄O₆·2HCl

Purity: ≥ 98.0%

Color and Shape: White to pale yellow powder or crystals

Molecular weight: 683.63

Ref: 7W-GP1065

Manidipine Dihydrochloride

Controlled Product

CAS: 89226-75-5

Applications Manidipine Dihydrochloride is a metabolite of Manidipine (M164000), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Meguro, K., et al.: Chem. Pharm. Bull., 33, 3787 (1985), Mizuno, K., et al.: Curr. Ther. Res., 52, 248 (1992); Hosaka, S., et al.: Chem. Pharma. Bulletin., 55, 793 (2007);

Formula: C₃₅H₃₈N₄O₆·2ClH

Color and Shape: Neat

Molecular weight: 683.6213

Ref: TR-M164015

Manidipine dihydrochloride

CAS: 89226-75-5

Manidipine is an antagonist of L-and T-type calcium channels that are present on smooth muscle cells. Manidipine is clinically used in hypertensive patients to achieve a significant peripheral vasodilation without an associated cardiodepression. In 2020, manidipine was identified as a potential drug in the treatment of COVID-19.

Formula: C₃₅H₃₈N₄O₆•(HCl)₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 683.62 g/mol

Ref: 3D-FM65072