CAS 892489-52-0

2-[4-[4-[[5-(3,4-difluoroanilino)-1,3,4-oxadiazole-2-carbonyl]amino]phenyl]cyclohexyl]acetic acid

Description:

The chemical substance known as 2-[4-[4-[[5-(3,4-difluoroanilino)-1,3,4-oxadiazole-2-carbonyl]amino]phenyl]cyclohexyl]acetic acid, with the CAS number 892489-52-0, is a complex organic compound characterized by its multi-functional structure. It features a cyclohexyl group, which contributes to its hydrophobic properties, and an acetic acid moiety that imparts acidic characteristics. The presence of a 1,3,4-oxadiazole ring enhances its potential for biological activity, often associated with pharmaceutical applications. Additionally, the difluoroaniline substituent suggests potential interactions in biological systems, possibly influencing its pharmacokinetics and pharmacodynamics. The compound's intricate structure may also indicate specific reactivity patterns, making it of interest in medicinal chemistry and drug development. Its solubility, stability, and reactivity would depend on various factors, including pH and solvent conditions, which are crucial for its application in research and industry. Overall, this compound exemplifies the complexity often found in drug-like molecules, combining various functional groups that can interact with biological targets.

Formula: C₂₃H₂₂F₂N₄O₄

InChI: InChI=1/C23H22F2N4O4/c24-18-10-9-17(12-19(18)25)27-23-29-28-22(33-23)21(32)26-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-20(30)31/h5-10,12-14H,1-4,11H2,(H,26,32)(H,27,29)(H,30,31)/t13-,14-

SMILES: C1C[C@@H](CC[C@H]1CC(=O)O)c1ccc(cc1)N=C(c1n[nH]c(=Nc2ccc(c(c2)F)F)o1)O

Synonyms:

• AZD-3988
• trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid
• AZD-3988; AZD3988; AZD 3988
• Cyclohexaneacetic acid, 4-[4-[[[5-[(3,4-difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]-, trans-
• trans-4-[4-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]cyclohexaneacetic acid

AZD3988

CAS: 892489-52-0

AZD3988

Purity: ≥98%

Molecular weight: 456.44g/mol

Ref: 54-BUP02141

AZD3988

CAS: 892489-52-0

AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity.

Formula: C₂₃H₂₂F₂N₄O₄

Purity: 99.19% - 99.32%

Color and Shape: Solid

Molecular weight: 456.44

Ref: TM-T14375

AZD 3988

CAS: 892489-52-0

AZD 3988 is a new drug candidate that has shown to have anticancer effects. It is an oxadiazole derivative and acts as a prodrug for the formation of cytotoxic metabolites. AZD 3988 has been shown to induce ferroptosis, a type of programmed cell death, in cancer cells. Ferroptosis is characterized by the accumulation of free iron and lipid peroxidation. The endoplasmic reticulum can be targeted by AZD 3988, leading to efficient cell death in vitro. In addition, AZD 3988 may also inhibit cholesterol acyltransferase activity and increase the expression of cholesterol ester transfer protein (CETP). These activities help to reduce serum levels of low-density lipoprotein cholesterol and increase high-density lipoprotein cholesterol levels.

Formula: C₂₃H₂₂F₂N₄O₄

Purity: Min. 95%

Molecular weight: 456.44 g/mol

Ref: 3D-FD102952