CAS 89270-28-0

(6S,9R,12R,15S,18S,30S)-33-[(1R,2R,4E)-1,6-dihydroxy-2-methylhex-4-en-1-yl]-30-ethyl-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20

Description:

The chemical substance with the name "(6S,9R,12R,15S,18S,30S)-33-[(1R,2R,4E)-1,6-dihydroxy-2-methylhex-4-en-1-yl]-30-ethyl-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20" and CAS number "89270-28-0" is a complex organic molecule characterized by its intricate structure, which includes multiple chiral centers and a significant number of carbon atoms. This compound features a large polycyclic framework, which is indicative of its potential biological activity. The presence of hydroxyl groups suggests it may exhibit hydrophilic properties, while the extensive alkyl chains contribute to its hydrophobic characteristics. Such structural features often influence the compound's solubility, stability, and interaction with biological systems. Additionally, the presence of nitrogen atoms in the structure indicates potential for forming hydrogen bonds, which can affect its reactivity and biological function. Overall, this compound's unique structural attributes may render it of interest in pharmaceutical or biochemical research, particularly in the context of drug development or as a biochemical probe.

Formula: C₆₂H₁₁₁N₁₁O₁₃

InChI: InChI=1/C62H111N11O13/c1-24-43-58(82)67(17)33-48(75)68(18)44(29-34(2)3)55(79)66-49(38(10)11)61(85)69(19)45(30-35(4)5)54(78)63-41(15)53(77)64-42(16)57(81)70(20)46(31-36(6)7)59(83)71(21)47(32-37(8)9)60(84)72(22)50(39(12)13)62(86)73(23)51(56(80)65-43)52(76)40(14)27-25-26-28-74/h25-26,34-47,49-52,74,76H,24,27-33H2,1-23H3,(H,63,78)(H,64,77)(H,65,80)(H,66,79)/b26-25+/t40-,41+,42-,43+,44?,45+,46-,47+,49?,50?,51?,52-/m1/s1

Synonyms:

• Csa m17
• Cyclosporin Metabolite 17
• Cyclosporin AM 1 (>80%)
• Cyclosporin AM 1
• Cyclosporin A Metabolite 17
• M 17
• Cyclosporine AM 1
• Cyclosporin A, 6-((3R,4R,6E)-6,7-didehydro-3,8-dihydroxy-N,4-dimethyl-L-2-aminooctanoic acid)-
• Cyclosporin A, 6-[(2S,3R,4R,6E)-3,8-dihydroxy-4-methyl-2-(methylamino)-6-octenoic acid]-
• OL 17
• Cyclosporin Impurity 26
• Hydroxycyclosporine
• Cyclosporin metabolite m17
• cyclosporine metabolite M17
• 6-[(2S,3R,4R,6E)-3,8-Dihydroxy-4-methyl-2-(methylamino)-6-octenoic acid]-cyclosporin A
• Cyclosporin AM 1 (&gt

Cyclosporin AM 1

CAS: 89270-28-0

Formula: C₆₂H₁₁₁N₁₁O₁₃

Molecular weight: 1218.63

Ref: 4Z-PC-5415

Cyclosporin AM 1 (>80%)

Controlled Product

CAS: 89270-28-0

Applications A cyclosporine metabolite specifically inhibits growth of renal cells in culture.
References Schultz, J.C.; et al.: Biochem. Pharma., 42, 1403 (1991), Johnson, B., et al.: Drug Metab. Dispos., 34, 556 (2006), Westley, I.S., Drug Metab. Dispos., 36, 46 (2008).

Formula: C₆₂H₁₁₁N₁₁O₁₃

Purity: >80%

Color and Shape: Neat

Molecular weight: 1218.61

Ref: TR-C988915

Cyclosporin AM 1-d3

Controlled Product

CAS: 89270-28-0

Formula: C₆₂D₃H₁₀₈N₁₁O₁₃

Color and Shape: Neat

Molecular weight: 1221.63

Ref: TR-C988917

Cyclosporin AM 1

CAS: 89270-28-0

Cyclosporin A is a cyclic nonapeptide that is an immunosuppressant drug. Cyclosporin A inhibits the production of interleukin-2 (IL-2) and other cytokines by human lymphocytes, and has been shown to suppress graft-versus-host disease in rat hepatocyte cultures. Cyclosporin A is a potent inhibitor of the enzyme cyclooxygenase, which converts arachidonic acid to prostaglandins such as PGE2. Cyclosporine A also binds to specific antibodies, or immunoglobulins, that are found in the blood plasma. This binding prevents the cells from reacting with each other and initiating a chain reaction. Cyclosporin AM 1 is a dry extract of cyclosporine prepared by spray drying that maintains its chemical stability and its pharmaceutical activity over time. It can be used as a coating for tablets or capsules or incorporated into the chemical composition of other products

Formula: C₆₂H₁₁₁N₁₁O₁₃

Purity: 80%Min

Color and Shape: White To Off-White Solid

Molecular weight: 1,218.61 g/mol

Ref: 3D-FC20753

Cyclosporin AM 1

CAS: 89270-28-0

Formula: C₆₂H₁₁₁N₁₁O₁₃

Molecular weight: 1218.6

Ref: ST-EA-CP-C162049