CAS 89430-38-6

(D-trp-7,9,10)-substance P

Description:

(D-Trp-7,9,10)-substance P, with the CAS number 89430-38-6, is a synthetic analog of the neuropeptide substance P, which is involved in various physiological processes, including pain perception, inflammation, and neurogenic responses. This compound is characterized by the substitution of D-tryptophan at specific positions (7, 9, and 10) in the peptide sequence, which alters its biological activity and receptor binding properties compared to the natural form of substance P. The modifications typically enhance its stability and may affect its affinity for neurokinin receptors, particularly NK1 receptors, which are primarily responsible for mediating the effects of substance P. As a result, (D-Trp-7,9,10)-substance P is often studied for its potential therapeutic applications in pain management and other conditions related to neuropeptide signaling. Its structural modifications also make it a valuable tool in pharmacological research aimed at understanding the role of substance P in various biological systems.

Formula: C₇₉H₁₀₅N₂₁O₁₃S

[D-Trp7,9,10]-Substance P

CAS: 89430-38-6

Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.

Formula: C₇₉H₁₀₅N₂₁O₁₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 1588.89

Ref: TM-TP1932

[D-Trp7,9,10]-Substance P

CAS: 89430-38-6

Substance P is a neuropeptide that functions as a neurotransmitter and neuromodulator. It has been shown to inhibit inflammatory mediator release and regulate immune responses. Substance P regulates the functioning of the central nervous system by acting on various types of receptors, including heterotrimeric G protein-coupled receptors, which are composed of alpha-, beta-, and gamma-subunits. This peptide also inhibits the production of proinflammatory cytokines in response to bacterial lipopolysaccharides (LPS). In addition, Substance P is involved in the regulation of retromer function. The administration of Substance P modulates the activity of protein kinases and alters cannabinoid signaling pathways.

Formula: C₇₉H₁₀₅N₂₁O₁₃S

Purity: Min. 95%

Molecular weight: 1,588.9 g/mol

Ref: 3D-PDA43038