CAS 89785-84-2

Tazobactam sodium

Description:

Tazobactam sodium is a beta-lactamase inhibitor commonly used in combination with certain antibiotics to enhance their efficacy against resistant bacterial strains. It is a white to off-white crystalline powder that is soluble in water, which facilitates its administration in clinical settings. Tazobactam functions by inhibiting the action of beta-lactamase enzymes produced by bacteria, which would otherwise degrade beta-lactam antibiotics, rendering them ineffective. This characteristic makes it particularly valuable in treating infections caused by beta-lactamase-producing organisms. The compound is typically administered intravenously and is often combined with piperacillin, forming a synergistic effect that broadens the antimicrobial spectrum. Tazobactam sodium is generally well-tolerated, but like all medications, it may have side effects, including allergic reactions or gastrointestinal disturbances. Its use is primarily in the treatment of serious infections, including those caused by Gram-negative bacteria, and it plays a crucial role in combating antibiotic resistance in clinical practice.

Formula: C₂₀H₁₉N₄NaO₅S

InChI: InChI=1/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m0./s1

InChI key: InChIKey=ZUNWFYFXHGWFRA-QVUDESDKSA-N

SMILES: C([C@@]1(C)[C@H](C(O)=O)N2[C@](S1(=O)=O)(CC2=O)[H])N3C=CN=N3.[Na]

Synonyms:

• 1H-1,2,3-Triazole, 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid deriv.
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt (1:1), (2S,3S,5R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt, (2S,3S,5R)-
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt, [2S-(2α,3β,5α)]-
• 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt, (2S,3S)- (1:1)
• Cl 307579
• Ytr 830
• sodium (2S,3S)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
• cl307579
• (2S,3R,5R)-3-Methyl-7-oxo-2-sodiooxycarbonyl-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane4,4-dioxide
• ytr830
• (2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid 4,4-dioxide Sodium Salt
• [2s-(2α,3β,5α)]-3-methyl-7-oxo-3(1h,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
• 3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-,4,4-dioxide,sodiumsalt,(2s-(2-alpha,3-beta,5-alp4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicaci
• [2s-(2a,3b,5a)]-3-methyl-7-oxo-3(1h,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium salt
• 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3-methyl-7-oxo-3-(1h-1,2,3
• TAZOBACTAMACID/SODIUM
• YTR-830H SODIUM SALT
• [2S-(2a,3b,5a)]-3-Methyl-7-oxo-3(1H,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide sodium salt
• CL-298741, YTR-830H, [2S-(2α, 3β, 5α)]-3-Methyl-7-oxo-3(1H,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
• 2-alpha-methyl-2-beta-(1,2,3-triazol-1-ylmethyl)penam-3-alpha-carboxylicacid
• [2S-(2ALPHA, 3BETA, 5ALPHA)]-3-METHYL-7-OXO-3(1H,2,3-TRIAZOL-1-YLMETHYL)-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID 4,4-DIOXIDE SODIUM SALT
• Piperacillin sodium salt
• CL-298741 SODIUM SALT
• -triazol-1-ylmethyl)-,4,4-dioxide,sodiumsalt,(2s-(2-alpha,3-beta,5-alpha))
• CL-30757
• TAZOBACTAM SODIUM SALT

Tazobactam sodium

CAS: 89785-84-2

Tazobactam sodium; Beta-Lactamase inhibitor, which is used with penicillinase inhibition studies and beta-lactam antibiotics to enhance their effect. It serves as an antibacterial penicillin derivative, which inhibits the action of bacterial beta-lactamases.

Formula: C₁₀H₁₁N₄NaO₅S

Color and Shape: Powder or crystalline powder or crystals, White to pale cream

Molecular weight: 322.27

Ref: 02-J66226

Tazobactam sodium

CAS: 89785-84-2

Formula: C₁₀H₁₁N₄NaO₅S

Purity: 90%

Color and Shape: Solid

Molecular weight: 322.2729

Ref: IN-DA003UHP

Tazobactam sodium

CAS: 89785-84-2

Tazobactam sodium,β-Lactamase inhibitor.

Formula: C₁₀H₁₁N₄NaO₅S

Purity: 98.56%

Color and Shape: Solid

Molecular weight: 322.27

Ref: TM-T1262L

Tazobactam sodium salt

CAS: 89785-84-2

Tazobactam sodium salt

Color and Shape: Solid

Molecular weight: 322.27g/mol

Ref: 54-BIT0158

Tazobactam sodium salt

CAS: 89785-84-2

Formula: C₁₀H₁₁N₄NaO₅S

Purity: ≥ 88.0% (Tazobactam, anhydrous)

Color and Shape: White to off-white crystalline powder

Molecular weight: 322.274

Ref: 7W-GA5074

Tazobactam Sodium Salt

CAS: 89785-84-2

Stability Hygroscopic
Applications β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.
References Gould, I.M., et al.: Drugs Exp. Clin. Res., 17, 187 (1991), Roland, R.K., et al.: J. Infect. Dis., 4, 226 (2000), Bonomo, R.A., et al.: Biochim. Biophys. Acta, 1547, 196 (2001),

Formula: C₁₀H₁₁N₄O₅S·Na

Color and Shape: Neat

Molecular weight: 322.27

Ref: TR-T010100

Tazobactam Sodium-15N3

CAS: 89785-84-2, 89786-04-9

Formula: C₁₀H₁₁N₁₅N₃NaO₅S

Color and Shape: White To Off-White

Molecular weight: 325.25

Ref: TR-T010103

Tazobactam sodium

CAS: 89785-84-2

Inhibitor of beta-lactamase; inhibitor of cell wall synthesis; beta-lactam class

Formula: C₁₀H₁₁NaN₄O₅S

Purity: Min. 90%

Color and Shape: Powder

Molecular weight: 322.27 g/mol

Ref: 3D-AT28013