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CAS 89785-84-2

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Tazobactam sodium

Description:
Tazobactam sodium is a beta-lactamase inhibitor commonly used in combination with certain antibiotics to enhance their efficacy against resistant bacterial strains. It is a white to off-white crystalline powder that is soluble in water, which facilitates its administration in clinical settings. Tazobactam functions by inhibiting the action of beta-lactamase enzymes produced by bacteria, which would otherwise degrade beta-lactam antibiotics, rendering them ineffective. This characteristic makes it particularly valuable in treating infections caused by beta-lactamase-producing organisms. The compound is typically administered intravenously and is often combined with piperacillin, forming a synergistic effect that broadens the antimicrobial spectrum. Tazobactam sodium is generally well-tolerated, but like all medications, it may have side effects, including allergic reactions or gastrointestinal disturbances. Its use is primarily in the treatment of serious infections, including those caused by Gram-negative bacteria, and it plays a crucial role in combating antibiotic resistance in clinical practice.
Formula:C20H19N4NaO5S
InChI:InChI=1/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m0./s1
InChI key:InChIKey=ZUNWFYFXHGWFRA-QVUDESDKSA-N
SMILES:C([C@@]1(C)[C@H](C(O)=O)N2[C@](S1(=O)=O)(CC2=O)[H])N3C=CN=N3.[Na]
Synonyms:
  • 1H-1,2,3-Triazole, 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid deriv.
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt (1:1), (2S,3S,5R)-
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt, (2S,3S,5R)-
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt, [2S-(2α,3β,5α)]-
  • 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt, (2S,3S)- (1:1)
  • Cl 307579
  • Ytr 830
  • sodium (2S,3S)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
  • cl307579
  • (2S,3R,5R)-3-Methyl-7-oxo-2-sodiooxycarbonyl-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane4,4-dioxide
  • See more synonyms
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