CAS 89987-06-4

Tiludronate

Description:

Tiludronate is a bisphosphonate compound primarily used in the treatment of Paget's disease of bone and osteoporosis. It functions by inhibiting osteoclast-mediated bone resorption, thereby helping to maintain bone density and strength. The chemical structure of tiludronate includes two phosphonate groups, which are essential for its biological activity. It is typically administered orally and has a relatively low bioavailability, necessitating specific dosing regimens. The substance is known for its ability to bind to hydroxyapatite in bone, which enhances its therapeutic effects. Common side effects may include gastrointestinal disturbances and, in rare cases, osteonecrosis of the jaw. Tiludronate is classified as a non-nitrogen-containing bisphosphonate, distinguishing it from other bisphosphonates that contain nitrogen in their structure. Its mechanism of action and therapeutic applications make it a significant agent in managing bone-related disorders. As with any medication, it is essential to consider contraindications and potential interactions with other drugs when prescribing tiludronate.

Formula: C₇H₉ClO₆P₂S

InChI: InChI=1S/C7H9ClO6P2S/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14/h1-4,7H,(H2,9,10,11)(H2,12,13,14)

InChI key: InChIKey=DKJJVAGXPKPDRL-UHFFFAOYSA-N

SMILES: C(SC1=CC=C(Cl)C=C1)(P(=O)(O)O)P(=O)(O)O

Synonyms:

• Tiludronic acid
• SR 41319
• Phosphonic acid, P,P′-[[(4-chlorophenyl)thio]methylene]bis-
• Phosphonic acid, [[(4-chlorophenyl)thio]methylene]bis-
• P,P′-[[(4-Chlorophenyl)thio]methylene]bis[phosphonic acid]

Disodium Tiludronate

CAS: 149845-07-8, 89987-06-4

Formula: C₇H₇ClNa₂O₆P₂S

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 362.56

Ref: 3B-D4167

Tiludronic acid

CAS: 89987-06-4

Formula: C₇H₇ClNa₂O₆P₂S·xH₂O

Molecular weight: 362.57 (anhydrous)

Ref: 7W-GP4498

Tiludronate disodium salt hydrate

CAS: 89987-06-4

Formula: ClNa

Molecular weight: 58.44

Ref: 7W-GP1931

Tiludronic Acid Disodium Salt

CAS: 149845-07-8, 89987-06-4

Formula: C₇H₇ClO₆P₂S·2Na

Molecular weight: 316.59 2 22.99

Ref: 4Z-T-260001

Tiludronate

CAS: 89987-06-4

Tiludronate, an oral bisphosphonate, treats metabolic bone disorders and inhibits osteoclasts.

Formula: C₇H₉ClO₆P₂S

Color and Shape: Solid

Molecular weight: 318.61

Ref: TM-T73056

Tiludronic acid

CAS: 89987-06-4

Tiludronic acid is a drug that belongs to the group of non-steroidal anti-inflammatory drugs. It is used for the treatment of bowel diseases such as inflammatory bowel disease, ulcerative colitis, and Crohn's disease. Tiludronic acid binds to the matrix metalloproteinases (MMPs) or collagenase, which are enzymes that break down connective tissue in the digestive system. This binding prevents their activity, thereby reducing inflammation and allowing damaged tissues to heal. Tiludronic acid has also been shown to have an activity index of 2.0 μM with respect to MMPs and collagenase in a model consisting of crystalline cellulose and experimental models. Tiludronic acid inhibits MMPs and collagenase by binding to them at low concentrations (2 μM). This binding prevents their activity, thereby reducing inflammation and allowing damaged tissues to heal. Tiludronic acid has also been shown to have an activity index

Formula: C₇H₇ClNa₂O₆P₂S

Purity: Min. 95%

Molecular weight: 362.57 g/mol

Ref: 3D-FT30708