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CAS 9001-40-5

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Glucose 6-phosphate dehydrogenase

Description:
Glucose 6-phosphate dehydrogenase (G6PD) is an enzyme that plays a crucial role in the pentose phosphate pathway, which is essential for cellular metabolism and the production of NADPH. This enzyme catalyzes the oxidation of glucose 6-phosphate to 6-phosphoglucono-δ-lactone, facilitating the generation of reducing equivalents in the form of NADPH. G6PD is a key player in protecting cells from oxidative stress by maintaining the balance of reduced glutathione, which is vital for detoxifying reactive oxygen species. The enzyme is widely distributed in various tissues, particularly in the liver and red blood cells. Deficiency in G6PD can lead to hemolytic anemia, especially under oxidative stress conditions, such as certain infections or exposure to specific drugs and foods. The enzyme is regulated by various factors, including substrate availability and allosteric effectors. Its activity can be influenced by genetic variations, which can lead to different phenotypes in populations, particularly in regions where malaria is endemic, as G6PD deficiency can confer some protection against the disease.
Formula:Unspecified
Synonyms:
  • 6-Phosphate 1-dehydrogenase
  • 6-Phosphoglucose dehydrogenase
  • <span class="text-smallcaps">D</span>-Glucose 6-phosphate dehydrogenase
  • <span class="text-smallcaps">D</span>-Glucose-6-phosphate:NADP 1-oxidoreductase
  • <span class="text-smallcaps">D</span>-Glucose-6-phosphate:NADP oxidoreductase
  • D-Glucose 6-phosphate dehydrogenase
  • Dehydrogenase, Glucose-, 6-Phosphat
  • Dehydrogenase, glucose 6-phosphate (nicotinamide adenine dinucleotide (phosphate))
  • Deshidrogenasa, Glucosa 6-Fosfato
  • Deshydrogenase, Phosphate-6 De Glucose
  • See more synonyms
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