CAS 9014-06-6

Penicillin amidase

Description:

Penicillin amidase, also known as penicillin acylase, is an enzyme that catalyzes the hydrolysis of penicillin and other β-lactam antibiotics, converting them into their corresponding acids and amino acids. This enzyme is crucial in the pharmaceutical industry for the production of semi-synthetic penicillins, as it facilitates the modification of penicillin structures to enhance their efficacy and stability. Penicillin amidase is typically derived from microbial sources, such as certain strains of bacteria, and exhibits optimal activity under specific pH and temperature conditions. The enzyme operates through a mechanism involving the formation of an acyl-enzyme intermediate, which is essential for its catalytic function. Its specificity can vary depending on the source, allowing for the selective hydrolysis of different penicillin derivatives. Additionally, penicillin amidase is of interest in biocatalysis due to its potential applications in the synthesis of various pharmaceuticals and in the development of biotransformation processes. Overall, this enzyme plays a significant role in both biochemistry and industrial applications related to antibiotic production.

Formula: Unspecified

Synonyms:

• Acylase, penicillin
• Amidasa, Penicilina
• Amidase, Penicilline
• Ampicillin acylase
• Assemblase
• Benzylpenicillin acylase
• Cephalosporin synthetase
• ChiroCLEC-EC
• E.C. 3.5.1.11
• Eupergit PcA 600
• Novozym 217
• Novozyme 217
• Pen-G acylase
• Penicillin G acylase
• Penicillin V acylase
• Penicillin V amidase
• Penicillin acylase
• Penicillin amidase
• Penicillin amidohydrolase
• Pga-450
• Phenoxymethylpenicillin amidohydrolase
• Semacylase
• α-Acylamino-β-lactam acylhydrolase
• β-Lactam acylase
• Amidase, penicillin
• Acylase from Escherichia coli Penicillin
• Penicillin Amidase solution from Escherichia coli

Penicillin amidase

CAS: 9014-06-6

Penicillin amidase cleaves penicillin for 6-APA production and antibiotic synthesis.

Color and Shape: White Solid

Ref: TM-T78361

Immobilized penicillin G acylase

CAS: 9014-06-6

Hydrolytic enzyme; biocatalyst in production of beta-lactam antibiotics

Color and Shape: White Beige Powder

Ref: 3D-FI76389

Penicillin amidase from escherichia coli

CAS: 9014-06-6

As a member of the family of hydrolases this enzyme acts on carbon-nitrogen bonds and may be used in the commercial production of semisynthetic penicillin.

Purity: Min. 95%

Ref: 3D-AP181614

Penicillin G acylase, 10mg/ml aqueous solution

CAS: 9014-06-6

Penicillin G acylase, 10mg/ml aqueous solution, is a biocatalytic enzyme used in pharmaceutical research and production. This enzyme is typically sourced from various microbial species, predominantly bacteria, through fermentation processes. Its primary mode of action involves the hydrolysis of penicillin G, catalyzing the cleavage of the side chain amide bond to produce 6-aminopenicillanic acid (6-APA), a core building block for the synthesis of a variety of semi-synthetic penicillins.

Purity: Min. 1000 U/Ml

Color and Shape: Brown Clear Liquid

Ref: 3D-FP161392