CAS 9015-68-3

L-Asparaginase

Description:

L-Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid and ammonia. It is primarily derived from bacterial sources, such as *Escherichia coli* and *Erwinia chrysanthemi*, and is classified as a hydrolase. This enzyme plays a crucial role in the treatment of certain types of leukemia, particularly acute lymphoblastic leukemia (ALL), by depriving cancer cells of asparagine, which they require for growth. L-Asparaginase exhibits specificity for the L-asparagine substrate and operates optimally at physiological pH and temperature. Its therapeutic use is associated with various side effects, including hypersensitivity reactions and potential effects on liver function. The enzyme is typically administered via injection, and its activity can be measured through various biochemical assays. Additionally, L-Asparaginase is subject to regulatory oversight due to its medical applications, and its production must adhere to stringent quality control standards to ensure safety and efficacy in clinical settings.

Formula: C₂₄H₂₄Cl₃N₃O₆

InChI: InChI=1/C15H16Cl3N3O2.C9H8O4/c1-2-4-20(15(22)21-5-3-19-10-21)6-7-23-14-12(17)8-11(16)9-13(14)18;1-6(10)13-8-5-3-2-4-7(8)9(11)12/h3,5,8-10H,2,4,6-7H2,1H3;2-5H,1H3,(H,11,12)

SMILES: CCCN(CCOc1c(cc(cc1Cl)Cl)Cl)C(=O)n1ccnc1.CC(=O)Oc1ccccc1C(=O)O

Synonyms:

• <span class="text-smallcaps">L</span>-Asnase
• <span class="text-smallcaps">L</span>-Asparaginase
• <span class="text-smallcaps">L</span>-Asparagine amidohydrolase
• Acrylaway L
• Asparaginasa
• Asparaginase
• Asparaginase 2
• Asparaginase medac
• Asparaginases
• Colaspase
• Crasnitin
• Crasnitins
• Crisantaspase
• E.C. 3.5.1.1
• Ec 3.5.1.1
• Elspar
• Erwinase
• Iub: 3.5.4.4
• Kidrolase
• Kidrolases
• L-Asnase
• L-Asparaginases
• L-Asparagine Amidohydrolase
• L-Asparagine amidohydrolases
• Leunase
• Leunases
• Mk 965
• Nsc 109229
• Oncospar
• PreventASe
• Preventase M
• Spectrila
• α-Asparaginase
• α-Asparaginases
• L-Asparaginase
• LASPAR
• l-asparaginasi
• kisrolase
• L-asparginase
• ASPARAGINASE FROM ESCHERICHIA COLISOLUTI ON IN GLYC
• ASPARAGINASE FROM ESCHERICHIA COLICHROMA TOGRAPHICA
• L-asparagise amidohydrolase
• asparaginase from escherichia coli
• re82-tad-15
• l-asparaginasex
• Crasnitin Elspar
• L-ASPARAGINASE FROM E. COLI, SUSPENSION, ~80 U/MG PROT.
• Asparaginase from Escherichia coli,L-Asparagine Amidohydrolase
• L-Asparaginase from Escherichia coli
• Sustanon Injection
• paronal
• ASPARAGINASE GRADE V FROM ESCHERICHIA CO
• L-ASPARAGINASE FROM E. COLI &
• Asparaginase, L-(escherichia coli)

Asparaginase

CAS: 9015-68-3

Ref: 7W-GZ5641

L-Asparaginase

CAS: 9015-68-3

L-Asparaginase

Color and Shape: Lyophilised Powder

Ref: 54-BITP1331

L-Asparaginase

CAS: 9015-68-3

L-Asparaginase, an enzyme for acute lymphoblastic leukemia treatment, is administered via injection.

Formula: NA

Purity: 97%

Color and Shape: Solid

Molecular weight: N/A

Ref: TM-TP1115

L-Asparaginase

CAS: 9015-68-3

Formula: C₁₃₇₇H₂₂₀₈N₃₈₂O₄₄₂S₁₇

Purity: ≥ 100U/mg

Color and Shape: White to almost white powder

Molecular weight: 31731.9

Ref: 7W-GX2339

Asparaginase 01

CAS: 9015-68-3

Asparaginase is an enzyme catalyzing the hydrolysis of I-asparagine to I-aspartic acid and ammonia and can be used clinically to treat lymphocytic leukemia as it deprives tumors of asparagine. Asparaginase is also useful in the food manufacturing process in reducing the production of acrylamide which is a carcinogen.

Ref: 3D-EASP01.6

L-Asparaginase

CAS: 9015-68-3

L-Asparaginase (EC 3.5.1.1) is an enzyme that catalyzes the following reaction: L-Asparagine + H2O → L-Aspartate + NH4+   One unit will yield 1.0 μmole of ammonia from L-asparagine per min at pH 8.6 and 37 °C.

Purity: Min. 95%

Ref: 3D-JAA01568