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CAS 9015-71-8

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Corticotropin-releasing factor

Description:
Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone (CRH), is a peptide hormone involved in the stress response. It is produced in the hypothalamus and plays a crucial role in the hypothalamic-pituitary-adrenal (HPA) axis by stimulating the release of adrenocorticotropic hormone (ACTH) from the pituitary gland. CRF is composed of 41 amino acids and exhibits a range of biological activities, including modulation of the immune response and influence on behavior and mood. The substance is characterized by its ability to bind to specific receptors, namely CRF receptors 1 and 2, which are distributed throughout the brain and peripheral tissues. CRF is also implicated in various physiological processes, including the regulation of circadian rhythms and the response to stressors. Its dysregulation is associated with several psychiatric and physiological disorders, making it a target for research in stress-related conditions. The CAS number 9015-71-8 uniquely identifies this peptide in chemical databases, facilitating its study and application in biomedical research.
Formula:C205H339N59O63S1
Synonyms:
  • ACTH - releasing factor
  • ACTH-releasing hormone
  • CRF
  • CRF (hormone)
  • CRH
  • Corticoliberin
  • Corticotrophin-releasing hormone
  • Corticotropin-Releasing Hormone
  • Corticotropin-releasing activity
  • Corticotropin-releasing hormone-41
  • See more synonyms
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Found 2 products.
  • CRF (Ovine)
    Biosynth
    + Info

    CRF (Ovine)

    CAS:
    <p>Corticotropin Releasing Factor (CRF) is a peptide hormone involved in the regulation of the neuroendocrine system, the hypothalamic-pituitary-adrenal (HPA) axis. The hypothalamus releases CRF during stress and in turn CRF stimulates the production of stress hormones such as glucocorticoids and adrenocorticotropin (ACTH). A negative feedback loop is created as glucocorticoids then prevents further endocrine activity exhibited by the pituitary gland and hypothalamus. Interestingly in patients with depression, it has been found that the hypothalamic-pituitary adrenal axis is over stimulated thus increased production of CRF occurs resulting in depression symptoms. Furthermore studies have shown the expression of CRF receptors in glial cells and T-cells and elevated levels of CRF and glucocorticoids prevent T-cell proliferation. During stress cytokines can also stimulate the secretion of CRF. However CRF can also regulate these cytokines. CRF has the potential to be used in the research into depression treatments. <br>This product is available as a 0.1mg vial.</p>
    Formula:C205H339N59O63S
    Purity:Min. 95%
    Molecular weight:4,670.3 g/mol

    Ref: 3D-PCR-4111-S

    100µg
    482.00€
  • CRF (Ovine)
    Biosynth
    + Info

    CRF (Ovine)

    CAS:
    <p>This product is an ovine, Corticotropin Release Factor (CRF) and is available as a 0.5mg vial. CRF is a peptide hormone and a key regulator of the hypothalamic-pituitary adrenal (HPA) axis. In response to stress the hypothalams releases CRF which stimulates the production of glucocorticoids and adrenocorticotropin, which are stress hormones. Glucocorticoids are then involved in a negative feedback loop, in that they prevent the pituitary gland and hypothalamus from exhibiting any further endocrine activity. Studies have shown that symptoms of depression can be caused by the over production of CRF due to the overstimulation of the hypothalamic-pituitary adrenal axis. Interestingly CRF receptors are expressed in both glial cells and T cells. Elevated levels of CRF and glucocorticoids prevent T-cell proliferation. During stress cytokines can also stimulate the secretion of CRF. However CRF can also regulate these cytokines. CRF has the potential to be used in the research into depression treatments.</p>
    Formula:C205H339N59O63S
    Purity:Min. 95%
    Molecular weight:4,670.3 g/mol

    Ref: 3D-PCR-4111-V

    500µg
    1,449.00€