CAS 902135-91-5

N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride

Description:

N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride, with the CAS number 902135-91-5, is a synthetic compound that belongs to the class of pyrazole derivatives. This substance typically exhibits characteristics such as being a white to off-white solid, which is soluble in polar solvents like water and methanol. It is often studied for its potential pharmacological properties, particularly in the context of its role as a therapeutic agent. The presence of the piperidine and dichlorobenzoyl moieties suggests that it may interact with biological targets, potentially influencing various signaling pathways. The hydrochloride salt form enhances its solubility and stability, making it suitable for pharmaceutical applications. As with many chemical compounds, safety data should be consulted to understand its toxicity, handling precautions, and environmental impact. Overall, this compound represents a significant interest in medicinal chemistry, particularly for its potential applications in drug development.

Formula: C₁₆H₁₇Cl₂N₅O₂.HCl

InChI: InChI=1S/C16H17Cl2N5O2.ClH/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);1H

SMILES: c1cc(c(c(c1)Cl)C(=Nc1c[nH]nc1C(=O)NC1CCNCC1)O)Cl.Cl

Synonyms:

• At 7519
• N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
• AT-7519(HCl)
• AT7519 HCl

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

CAS: 902135-91-5

Formula: C₁₆H₁₈Cl₃N₅O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 418.7054

Ref: IN-DA00GRUQ

AT7519 Hydrochloride

CAS: 902135-91-5

AT7519 Hydrochloride

Purity: ≥98%

Molecular weight: 418.71g/mol

Ref: 54-BUP10160

AT7519 hydrochloride

CAS: 902135-91-5

Ref: 7W-GW4564

AT7519 Hydrochloride

CAS: 902135-91-5

AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.

Formula: C₁₆H₁₈Cl₃N₅O₂

Purity: 99.66% - 99.9%

Color and Shape: Solid

Molecular weight: 418.71

Ref: TM-T1778

4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl

CAS: 902135-91-5

4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl (PD1693) is a small molecule that has been shown to selectively inhibit the transcriptional coactivator HIF-1α. PD1693 inhibits the hypoxic response in tumor cells by preventing the upregulation of HIF-1α. This leads to an increase in hypoxia-inducible genes, which are involved in the regulation of cell proliferation, angiogenesis and apoptosis. PD1693 also affects the expression of genes involved in metabolism and energy production. The subpopulation algorithm was used to identify differentially expressed transcripts in glioma cells following exposure to PD1693. The data from this algorithm were validated using qRT-PCR and Western blotting on human glioma cells.

Formula: C₁₆H₁₇Cl₂N₅O₂·HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 418.7 g/mol

Ref: 3D-FD32785

AT7519 hydrochloride

CAS: 902135-91-5

Purity: 99%

Molecular weight: 417.053

Ref: 10-F857780