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CAS 90332-63-1

:

7-Xylosyl-10-deacetyltaxol

Description:
7-Xylosyl-10-deacetyltaxol, identified by its CAS number 90332-63-1, is a chemical compound derived from the taxane family, which is known for its significant role in cancer treatment, particularly in the formulation of chemotherapeutic agents like paclitaxel. This compound features a xylosyl sugar moiety attached to the taxane structure, which may influence its solubility, stability, and biological activity. The presence of the deacetyl group suggests that it may exhibit different pharmacological properties compared to its acetylated counterparts. Generally, taxanes are characterized by their ability to inhibit microtubule depolymerization, thereby disrupting normal cell division, which is a critical mechanism in cancer therapy. The specific characteristics of 7-Xylosyl-10-deacetyltaxol, including its molecular weight, solubility, and biological activity, would be essential for understanding its potential therapeutic applications and efficacy. Further studies would be necessary to elucidate its pharmacokinetics, toxicity, and overall role in medicinal chemistry.
Formula:C50H57NO17
InChI:InChI=1S/C50H57NO17/c1-25-31(65-45(61)38(56)35(27-15-9-6-10-16-27)51-43(59)28-17-11-7-12-18-28)22-50(62)42(67-44(60)29-19-13-8-14-20-29)40-48(5,41(58)37(55)34(25)47(50,3)4)32(21-33-49(40,24-64-33)68-26(2)52)66-46-39(57)36(54)30(53)23-63-46/h6-20,30-33,35-40,42,46,53-57,62H,21-24H2,1-5H3,(H,51,59)/t30-,31+,32+,33-,35+,36+,37-,38-,39-,40+,42+,46+,48-,49+,50-/m1/s1
InChI key:InChIKey=ORKLEZFXASNLFJ-DYLQFHMVSA-N
SMILES:O(C(C)=O)[C@]12[C@@]3([C@@](C)([C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)CO4)C[C@]1(OC2)[H])C(=O)[C@H](O)C=5C(C)(C)[C@](O)([C@H]3OC(=O)C6=CC=CC=C6)C[C@H](OC([C@@H]([C@@H](NC(=O)C7=CC=CC=C7)C8=CC=CC=C8)O)=O)C5C)[H]
Synonyms:
  • 10-Deacetyl-7-xylosylpaclitaxel
  • 10-Deacetyl-7-xylosyltaxol
  • 10-Deacetylpaclitaxel 7-xyloside
  • 10-Deacetyltaxol 7-xyloside
  • 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
  • 7-Xylosyl-10-deacetylpaclitaxel
  • 7β-Xylosyl-10-deacetyltaxol
  • Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-<span class="text-smallcaps">D</span>-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
  • Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-<span class="text-smallcaps">D</span>-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
  • b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
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