CAS 90332-63-1

7-Xylosyl-10-deacetyltaxol

Description:

7-Xylosyl-10-deacetyltaxol, identified by its CAS number 90332-63-1, is a chemical compound derived from the taxane family, which is known for its significant role in cancer treatment, particularly in the formulation of chemotherapeutic agents like paclitaxel. This compound features a xylosyl sugar moiety attached to the taxane structure, which may influence its solubility, stability, and biological activity. The presence of the deacetyl group suggests that it may exhibit different pharmacological properties compared to its acetylated counterparts. Generally, taxanes are characterized by their ability to inhibit microtubule depolymerization, thereby disrupting normal cell division, which is a critical mechanism in cancer therapy. The specific characteristics of 7-Xylosyl-10-deacetyltaxol, including its molecular weight, solubility, and biological activity, would be essential for understanding its potential therapeutic applications and efficacy. Further studies would be necessary to elucidate its pharmacokinetics, toxicity, and overall role in medicinal chemistry.

Formula: C₅₀H₅₇NO₁₇

InChI: InChI=1S/C50H57NO17/c1-25-31(65-45(61)38(56)35(27-15-9-6-10-16-27)51-43(59)28-17-11-7-12-18-28)22-50(62)42(67-44(60)29-19-13-8-14-20-29)40-48(5,41(58)37(55)34(25)47(50,3)4)32(21-33-49(40,24-64-33)68-26(2)52)66-46-39(57)36(54)30(53)23-63-46/h6-20,30-33,35-40,42,46,53-57,62H,21-24H2,1-5H3,(H,51,59)/t30-,31+,32+,33-,35+,36+,37-,38-,39-,40+,42+,46+,48-,49+,50-/m1/s1

InChI key: InChIKey=ORKLEZFXASNLFJ-DYLQFHMVSA-N

SMILES: O(C(C)=O)[C@]12[C@@]3([C@@](C)([C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@H](O)CO4)C[C@]1(OC2)[H])C(=O)[C@H](O)C=5C(C)(C)[C@](O)([C@H]3OC(=O)C6=CC=CC=C6)C[C@H](OC([C@@H]([C@@H](NC(=O)C7=CC=CC=C7)C8=CC=CC=C8)O)=O)C5C)[H]

Synonyms:

• 10-Deacetyl-7-xylosylpaclitaxel
• 10-Deacetyl-7-xylosyltaxol
• 10-Deacetylpaclitaxel 7-xyloside
• 10-Deacetyltaxol 7-xyloside
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7-Xylosyl-10-deacetylpaclitaxel
• 7β-Xylosyl-10-deacetyltaxol
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-<span class="text-smallcaps">D</span>-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-<span class="text-smallcaps">D</span>-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(β-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

7-Xylosyl-10-deacetyltaxol

CAS: 90332-63-1

Formula: C₅₀H₅₇NO₁₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 943.9841

Ref: IN-DA00IG3O

10-Deacetyl-7-xylosyl paclitaxel

CAS: 90332-63-1

10-Deacetyl-7-xylosyl paclitaxel

Purity: ≥95%

Molecular weight: 943.98g/mol

Ref: 54-OR1031587

10-Deacetyl-7-xylosyl paclitaxel

CAS: 90332-63-1

Formula: C₅₀H₅₇NO₁₇

Molecular weight: 944.00

Ref: 7W-GY0774

10-Deacetyl-7-Xylosyl Paclitaxel

CAS: 90332-63-1

Formula: C₅₀H₅₇NO₁₇

Color and Shape: White To Off-White Solid

Molecular weight: 944.00

Ref: 4Z-P-2863

10-O-Deacetyl-7-O-(β-xylosyl)paclitaxel

CAS: 90332-63-1

Color and Shape: Neat

Ref: 86-MM1489.13

10-Deacetyl-7-xylosyl paclitaxel

CAS: 90332-63-1

10-Deacetyl-7-xylosyl paclitaxel has long been used in Chinese clinics to treat cancer, it may target mitochondrial permeability transition pore (mPTP).

Formula: C₅₀H₅₇NO₁₇

Purity: 95%~99%

Molecular weight: 943.996

Ref: BP-SBP03710

10-Deacetyl-7-xylosyl paclitaxel

CAS: 90332-63-1

10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility.

Formula: C₅₀H₅₇NO₁₇

Purity: 99.76% - ≥95%

Color and Shape: Solid

Molecular weight: 943.98

Ref: TM-T5749

10-Deacetyl-7-xylosyl paclitaxel

CAS: 90332-63-1

Ref: BE-RMCP002056

10-Deacetyl-7-xylosyl Paclitaxel (62%)

Controlled Product

CAS: 90332-63-1

Impurity Paclitaxel - In House Impurity
Stability Hygroscopic
Applications A metabolite of Paclitaxel (P132500). Paclitaxel - In House Impurity.
References Gut, I., et al.: Xenobiotica, 36, 772 ( 2006), Zhang, J., et al.: Drug Metab. Dispos., 36, 418 (2008), Li, S., et al.: J. Pharm. Biomed. Anal., 49, 81, (2009),

Formula: C₅₀H₅₇NO₁₇

Purity: 62%

Color and Shape: Neat

Molecular weight: 943.98

Ref: TR-D198965

7-Xylosyl-10-deacetyltaxol

CAS: 90332-63-1

7-Xylosyl-10-deacetyltaxol is a plant chemical that is found in the needles of the Taxus cuspidata tree. This compound has been shown to inhibit prostate cancer cells and has been clinically used as an adjuvant agent for cancer treatment. 7-Xylosyl-10-deacetyltaxol binds to prostate cancer cells and inhibits their growth, which may be due to its ability to inhibit cell cycle progression at the G2/M phase transition. It also has a strong inhibitory effect on test samples from human prostate cancer cells. In addition, it inhibits enzyme activities that are involved in the biosynthesis of membrane lipids, such as phospholipase A2, arachidonate 12-lipoxygenase, and cyclooxygenase 2. 7-Xylosyl-10-deacetyltaxol also inhibits enzyme activities in cell culture that are involved in the synthesis of carbon

Formula: C₅₀H₅₇NO₁₇

Purity: Min. 95%

Molecular weight: 943.98 g/mol

Ref: 3D-MX20833

10-Deacetyl-7-xylosyl Paclitaxel

CAS: 90332-63-1

Formula: C₅₀H₅₇NO₁₇

Molecular weight: 944.00

Ref: ST-EA-CP-P36087