CAS 90365-57-4

(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one

Description:

Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2?Directs differentiation of human and mouse ESCs to pancreatic cells.3?? May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4?Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5

Formula: C₁₇H₂₃N₃O₂

InChI: InChI=1/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)/t12-,16-/m0/s1

InChI key: InChIKey=LUZOFMGZMUZSSK-LRDDRELGSA-N

SMILES: CN1C2=C3C(C[C@@H](CO)NC(=O)[C@@H]1[C@@H](C)C)=CNC3=CC=C2

Synonyms:

• (-)-Ilv
• (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
• (2S,5S)-5-(hydroxymethyl)-1-methyl-2-(propan-2-yl)-1,2,4,5,6,8-hexahydro-3H-[1,4]diazonino[7,6,5-cd]indol-3-one
• 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)-
• 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))-
• Brn 4711877
• (-)-Indolactam V
• Indolactam V
• 3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym
• (-)-Indolactam V&nbsp
• IndolactaM

(-)-Indolactam V

CAS: 90365-57-4

(-)-Indolactam V

Formula: C₁₇H₂₃N₃O₂

Purity: 99.30%

Molecular weight: 301.38

Ref: 54-OR1111950

(-)-Indolactam V

CAS: 90365-57-4

Formula: C₁₇H₂₃N₃O₂

Purity: 99.30%

Color and Shape: Solid

Molecular weight: 301.3834

Ref: IN-DA006QY8

(-)-Indolactam V

CAS: 90365-57-4

Formula: C₁₇H₂₃N₃O₂

Purity: ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 301.4

Ref: 7W-GL4102

(-)-Indolactam V

CAS: 90365-57-4

Formula: C₁₇H₂₃N₃O₂

Purity: 99.30%

Molecular weight: 301.39

Ref: 10-F050739

(-)-Indolactam V

Controlled Product

CAS: 90365-57-4

Formula: C₁₇H₂₃N₃O₂

Color and Shape: Neat

Molecular weight: 301.383

Ref: TR-I577325

(-)-Indolactam V-d8

Controlled Product

CAS: 90365-57-4

Formula: C₁₇D₈H₁₅N₃O₂

Color and Shape: Neat

Molecular weight: 309.433

Ref: TR-I577327

(-)-Indolactam V

CAS: 90365-57-4

(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.

Formula: C₁₇H₂₃N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 301.38

Ref: TM-T17299