CAS 905281-76-7

2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-pyridin-4-yl-1H-pyrazol-1-yl}ethanol

Description:

The chemical substance known as 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-pyridin-4-yl-1H-pyrazol-1-yl}ethanol, with the CAS number 905281-76-7, is a complex organic compound characterized by its multi-functional structure. It features a hydroxylamine moiety, which is indicative of its potential reactivity and ability to form hydrogen bonds, enhancing its solubility in polar solvents. The presence of a pyrazole and pyridine ring suggests that it may exhibit interesting biological activities, possibly acting as a ligand or inhibitor in various biochemical pathways. The indene derivative contributes to its unique three-dimensional conformation, which may influence its interaction with biological targets. Additionally, the ethanol group suggests that it may have applications in medicinal chemistry, particularly in drug design, due to its potential for modulating biological activity. Overall, this compound's structural complexity and functional groups make it a candidate for further investigation in pharmacological studies.

Formula: C₁₉H₁₈N₄O₂

InChI: InChI=1/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,24-25H,2,4,9-10H2/b22-18+

Synonyms:

• Gdc-0879

GDC-0879

CAS: 905281-76-7

GDC-0879

Purity: ≥95%

Molecular weight: 334.37g/mol

Ref: 54-BUP12750

Gdc-0879

CAS: 905281-76-7

Gdc-0879

Purity: 98%

Molecular weight: 334.37g/mol

Ref: 54-BISN0238

GDC-0879 Hydrochloride

Controlled Product

CAS: 905281-76-7

Stability Hygroscopic
Applications GDC-0879 is a RAF inhibitor used in the treatment of melanoma tumors associated with the BRAF serine/threonine kinase.
References Hoeflich, K. et al.: Canc. Res., 69, 3042 (2009); Hansen, J. ET AL.: Bioorg. Med. Chem. Lett., 18, 4692 (2008);

Formula: C₁₉H₁₉ClN₄O₂

Color and Shape: Neat

Molecular weight: 370.83

Ref: TR-G299980

GDC 0879

CAS: 905281-76-7

Mutant BRAF (BRAFV600E) inhibitor

Purity: Min. 95%

Ref: 3D-FH43320

GDC-0879

CAS: 905281-76-7

GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.

Formula: C₁₉H₁₈N₄O₂

Purity: 99.62%

Color and Shape: Solid

Molecular weight: 334.37

Ref: TM-T6320