CAS 905579-51-3

Pevonedistat

Description:

Pevonedistat, with the CAS number 905579-51-3, is a small molecule inhibitor that primarily targets the NEDD8-activating enzyme (NAE), which plays a crucial role in the ubiquitin-proteasome system. This inhibition disrupts the neddylation process, leading to the accumulation of proteins that are normally degraded, thereby affecting various cellular pathways, including those involved in cell cycle regulation and apoptosis. Pevonedistat has shown potential in the treatment of various cancers, particularly hematological malignancies, and is being investigated in clinical trials. The compound is characterized by its ability to induce cell death in cancer cells and enhance the efficacy of other therapeutic agents. Its chemical structure includes a unique combination of functional groups that contribute to its biological activity. As a research compound, Pevonedistat is of significant interest in oncology, particularly for its potential to overcome resistance to existing therapies. However, like many investigational drugs, its safety and efficacy profiles are still being evaluated in clinical settings.

Formula: C₂₁H₂₅N₅O₄S

InChI: InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1

InChI key: InChIKey=MPUQHZXIXSTTDU-QXGSTGNESA-N

SMILES: N(C1=C2C(N(C=C2)[C@@H]3C[C@@H](COS(N)(=O)=O)[C@@H](O)C3)=NC=N1)[C@@H]4C=5C(CC4)=CC=CC5

Synonyms:

• MLN 4924
• Pevonedistat
• Sulfamic acid, [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester

Sulfamic acid [(1S,2S,4R)-4-[4-[[(1S)-2,3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester

CAS: 905579-51-3

Formula: C₂₁H₂₅N₅O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 443.5193

Ref: IN-DA00GU4G

((1S,2S,4R)-4-(4-(((S)-2,3-Dihydro-1H-Inden-1-Yl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl)-2-Hydroxycyclopentyl)Methyl Sulfamate

CAS: 905579-51-3

((1S,2S,4R)-4-(4-(((S)-2,3-Dihydro-1H-Inden-1-Yl)Amino)-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl)-2-Hydroxycyclopentyl)Methyl Sulfamate

Purity: 98%

Molecular weight: 443.52g/mol

Ref: 54-OR1023325

Pevonedistat

CAS: 905579-51-3

Pevonedistat

Purity: ≥95%

Molecular weight: 443.52g/mol

Ref: 54-BUP15281

Pevonedistat

CAS: 905579-51-3

Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM).

Formula: C₂₁H₂₅N₅O₄S

Purity: 95% - 99.92%

Color and Shape: Solid

Molecular weight: 443.52

Ref: TM-T6332

MLN 4924

CAS: 905579-51-3

Formula: C₂₁H₂₅N₅O₄S

Purity: ≥ 98.0%

Color and Shape: White solid

Molecular weight: 443.52

Ref: 7W-GC3946

MLN 4924

CAS: 905579-51-3

MLN 4924 is a selective small molecule that acts as an inhibitor of the Nedd8-activating enzyme. This compound is synthetically derived and functions by inhibiting the conjugation of Nedd8 to cullin proteins. By blocking this pathway, MLN 4924 disrupts the activity of the SCF (Skp, Cullin, F-box containing complex) E3 ubiquitin ligase, leading to an accumulation of proteins that can induce apoptosis and cell cycle arrest.

Formula: C₂₁H₂₅N₅O₄S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 443.52 g/mol

Ref: 3D-FM16807

MLN 4924

Controlled Product

CAS: 905579-51-3

Applications A potent and selective inhibitor of NAE. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. The ubiquitin-proteasome pathway mediates the destruction of unwanted proteins. Potent NAE inhibitor; NEDD8 E1 Activating Enzyme Inhibitor.
References Haas, A., et al.: J. Biol. Chem., 257, 10329 (1982), Walden, H., et al.: Nature, 422, 330 (2003), Kane, R., et al.: Clin. Cancer Res., 13, 5291 (2007), Saha, A., et al.: Mol. Cell., 32, 21 (2008),

Formula: C₂₁H₂₅N₅O₄S

Color and Shape: Neat

Molecular weight: 443.52

Ref: TR-M425100