CAS 90614-49-6

L-Valyl-L-prolyl-L-leucine

Description:

L-Valyl-L-prolyl-L-leucine, with the CAS number 90614-49-6, is a tripeptide composed of three amino acids: valine, proline, and leucine. This compound is characterized by its specific sequence, which influences its structural and functional properties. As a peptide, it exhibits characteristics typical of amino acids, including the ability to form hydrogen bonds and participate in various biochemical interactions. The presence of proline, known for its unique cyclic structure, can impart rigidity to the peptide chain, affecting its conformation and stability. L-Valyl-L-prolyl-L-leucine may play a role in biological processes, potentially influencing protein folding, enzyme activity, or cellular signaling pathways. Additionally, peptides like this one are often studied for their potential therapeutic applications, including their roles in drug design and development. Its solubility, stability, and reactivity can vary based on environmental conditions such as pH and temperature, making it a subject of interest in both biochemical research and pharmaceutical formulations.

Formula: C₁₆H₂₉N₃O₄

InChI: InChI=1/C16H29N3O4/c1-9(2)8-11(16(22)23)18-14(20)12-6-5-7-19(12)15(21)13(17)10(3)4/h9-13H,5-8,17H2,1-4H3,(H,18,20)(H,22,23)

InChI key: InChIKey=NHXZRXLFOBFMDM-AVGNSLFASA-N

SMILES: C([C@H](C(C)C)N)(=O)N1[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCC1

Synonyms:

• 468: PN: WO2005081628 SEQID: 470 claimed protein
• <span class="text-smallcaps">L</smallcap>-Leucine, <smallcap>L</smallcap>-valyl-<smallcap>L</span>-prolyl-
• <span class="text-smallcaps">L</smallcap>-Leucine, N-(1-<smallcap>L</smallcap>-valyl-<smallcap>L</span>-prolyl)-
• <span class="text-smallcaps">L</smallcap>-Valyl-<smallcap>L</smallcap>-prolyl-<smallcap>L</span>-leucine
• H-Val-Pro-Leu-OH
• L-valyl-L-prolyl-L-leucine
• Valylprolylleucine
• Diprotin B
• L-Leucine, L-valyl-L-prolyl-
• L-Leucine, N-(1-L-valyl-L-prolyl)-
• (-)-L-Val-L-Pro-L-Leu-OH
• L-VALYL-L-PROLYL LEUCINE
• VAL-PRO-LEU
• n-(1-l-valyl-l-prolyl)-l-leucin
• Val-Pro-Leu-OH
• 2-[[1-(2-amino-3-methylbutanoyl)pyrrolidine-2-carbonyl]amino]-4-methylpentanoic acid

L-Leucine, L-valyl-L-prolyl-

CAS: 90614-49-6

Formula: C₁₆H₂₉N₃O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 327.4192

Ref: IN-DA00IG8H

Diprotin B

CAS: 90614-49-6

Diprotin B

Purity: 98%

Molecular weight: 327.42g/mol

Ref: 54-OR1035879

Diprotin B

CAS: 90614-49-6

Formula: C₁₆H₂₉N₃O₄

Molecular weight: 327.40

Ref: 7W-GA4837

Diprotin B

CAS: 90614-49-6

Diprotin B is a colony-stimulating factor protein that has inhibitory properties in the colon. It has been shown to be effective in reducing symptoms of bowel disease and inflammatory bowel disease, as well as reducing the recurrence of colon cancer. Diprotin B inhibits the release of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The inhibition of these proinflammatory cytokines may contribute to the anti-inflammatory effects observed with Diprotin B treatment. Diprotin B also prevents cytosolic calcium accumulation, which can lead to cell lysis. This process is mediated by antimicrobial peptides called defensins that are expressed in Paneth cells found in the small intestine and colon. Defensins have also been shown to induce cell lysis through their ability to bind to bacterial membranes.

Formula: C₁₆H₂₉N₃O₄

Purity: Min. 95%

Molecular weight: 327.43 g/mol

Ref: 3D-IDB-3982-PI

Diprotin B

CAS: 90614-49-6

Diprotin B is a dipeptidyl peptidase IV inhibitor.

Formula: C₁₆H₂₉N₃O₄

Purity: 98%

Color and Shape: White Lyophilized Powder

Molecular weight: 327.42

Ref: TM-T25341

Diprotin B

CAS: 90614-49-6

Diprotin B is a peptide that is the most potent inhibitor of serine proteases identified to date. It has been shown to inhibit both chymotrypsin and trypsin, with an IC50 value of 0.5 nM for chymotrypsin and 2 nM for trypsin. Diprotin B is able to inhibit the enzymatic activity by protonation at the catalytic residue, S2, in the active site of serine proteases. The efficiency of this inhibition can be increased by altering pH or adding proton donors such as HCl or NaOH. This peptide also hydrolyzes at a slower rate than the substrate (chymotrypsin). Diprotin B has a molecular weight of 906 Da and contains two amino acids: valine (Val) and leucine (Leu). It contains no functional groups that would be expected to affect its inhibitory properties.

Formula: C₁₆H₂₉N₃O₄

Purity: Min. 95%

Molecular weight: 327.42 g/mol

Ref: 3D-FD109478