CAS 90729-43-4

Ebastine

Description:

Ebastine is a second-generation antihistamine primarily used to alleviate allergic symptoms such as rhinitis and urticaria. It functions as a selective antagonist of the H1 histamine receptor, which helps reduce the effects of histamine in the body, thereby mitigating allergic reactions. Ebastine is characterized by its relatively low sedative effects compared to first-generation antihistamines, making it suitable for long-term use without significant drowsiness. The substance is typically administered orally and is known for its rapid absorption and metabolism, with a half-life that allows for once-daily dosing. Chemically, ebastine is a piperidine derivative, and its structure includes a phenyl group, contributing to its pharmacological activity. It is generally well-tolerated, with a side effect profile that may include headache, fatigue, and dry mouth, although these are less common. Ebastine is also notable for its ability to cross the blood-brain barrier to a lesser extent than older antihistamines, which is a key factor in its reduced sedative properties.

Formula: C₃₂H₃₉NO₂

InChI: InChI=1/C32H39NO2/c1-32(2,3)28-18-16-25(17-19-28)30(34)15-10-22-33-23-20-29(21-24-33)35-31(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-9,11-14,16-19,29,31H,10,15,20-24H2,1-3H3

InChI key: InChIKey=MJJALKDDGIKVBE-UHFFFAOYSA-N

SMILES: C(OC1CCN(CCCC(=O)C2=CC=C(C(C)(C)C)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4

Synonyms:

• 1-(4-(1,1-Dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-1-butanone
• 1-(4-Tert-Butylphenyl)-4-[4-(Diphenylmethoxy)Piperidin-1-Yl]Butan-1-One
• 1-Butanone, 1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidinyl)-
• 4'-tert-Butyl-4-(4-(diphenylmethoxy)piperidino)butyrophenone
• 4-Diphenylmethoxy-1-(3-(4-tert-butylbenzoyl)propyl)piperidine
• Bastel
• Ebastel
• Ebastin
• Ebastina
• Ebastina [Spanish]
• Ebastine [USAN:INN]
• Ebastinum
• Ebastinum [Latin]
• Erostin
• Kestine
• Las W-090
• Rp 64305
• Unii-Tqd7Q784P1
• Ebastine
• EBASTINE, IMPURITY C4-(DIPHENYLMETHOXY)PIPERIDINE EP STANDARD
• 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one
• Ebasine
• EBASTINE, IMPURITY D1-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(4-HYDROXYPIPERIDIN-1-YL)BUTAN-1-ONE EP STANDARD
• 1-butanone,1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidiny
• Estivan
• EVASTEL
• EBASTINE, MM STANDARD
• EBASTINE, REFERENCE SPECTRUM EP STANDARD

Ebastine

CAS: 90729-43-4

A histamine H1 receptor antagonist

Formula: C₃₂H₃₉NO₂

Molecular weight: 469.66

Ref: 02-J63088

EBASTINE CRS

CAS: 90729-43-4

EBASTINE CRS

Ref: 41-Y0002031

Ebastine

CAS: 90729-43-4

Formula: C₃₂H₃₉NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 469.6576

Ref: IN-DA003PWW

Ebastine

CAS: 90729-43-4

Ebastine

Purity: ≥98%

Molecular weight: 469.66g/mol

Ref: 54-BUP18121

Ebastine

CAS: 90729-43-4

Formula: C₃₂H₃₉NO₂

Color and Shape: Off-White Solid

Molecular weight: 469.67

Ref: 4Z-E-171

Ebastine

CAS: 90729-43-4

Ebastine

Purity: 99%

Molecular weight: 469.66g/mol

Ref: 54-OR1028756

Ebastine

CAS: 90729-43-4

Formula: C₃₂H₃₉NO₂

Molecular weight: 469.66

Ref: 7W-GP5991

Ebastine

CAS: 90729-43-4

Color and Shape: Neat

Ref: 86-MM0468.00

Ebastine

CAS: 90729-43-4

Formula: C₃₂H₃₉NO₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 469.67

Ref: 3B-E0925

Ebastine

CAS: 90729-43-4

Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine.

Formula: C₃₂H₃₉NO₂

Purity: 99.65% - 99.99%

Color and Shape: White To Off-White Powder

Molecular weight: 469.66

Ref: TM-T2335

Ebastine

CAS: 90729-43-4

Applications A nonsedating type histamine H1-receptor antagonist. Antihistaminic.
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Inomata, N., et al.: J. Dermatol., 36, 224 (2009), Carvajal, A., et al.: Clin. Pharmacol. Ther., 85, 481 (2009), Yamashita, S., et al.: Mol. Pharm., 6, 48 (2009),

Formula: C₃₂H₃₉NO₂

Color and Shape: White To Off-White

Molecular weight: 469.66

Ref: TR-E320000

Ebastine

CAS: 90729-43-4

Ebastine is a H1 receptor antagonist that belongs to the group of antihistamines. Ebastine inhibits histamine release from mast cells and basophils and may also have some anticancer activity. It has been shown to be effective in clinical trials, used to treat rhinitis and allergic symptoms such as itching and watery eyes. Ebastine is also non-sedating is not metabolized by cytochrome P450 enzymes but may affect their activity due to its binding affinity for proteins such as albumin and α1-acid glycoprotein.

Formula: C₃₂H₃₉NO₂

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 469.66 g/mol

Ref: 3D-FE22636

Ebastine - Bio-X ™

CAS: 90729-43-4

Ebastine is a H1 receptor antagonist that belongs to the group of antihistamines. Ebastine inhibits histamine release from mast cells and basophils and may also have some anticancer activity. It has been shown to be effective in clinical trials, used to treat rhinitis and allergic symptoms such as itching and watery eyes. Ebastine is also non-sedating is not metabolized by cytochrome P450 enzymes but may affect their activity due to its binding affinity for proteins such as albumin and α1-acid glycoprotein.

Formula: C₃₂H₃₉NO₂

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 469.66 g/mol

Ref: 3D-BE164400

Ebastine

CAS: 90729-43-4

Color and Shape: Neat

Ref: 61-FOR0468.00