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CAS 91161-71-6

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Terbinafine

Description:
Terbinafine is an antifungal medication primarily used to treat fungal infections, particularly those affecting the skin and nails, such as athlete's foot, ringworm, and onychomycosis. It belongs to the allylamine class of antifungals and works by inhibiting the enzyme squalene epoxidase, which is crucial in the biosynthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to cell death and effectively clears the infection. Terbinafine is available in various forms, including oral tablets and topical creams or gels. It is generally well-tolerated, but potential side effects may include gastrointestinal disturbances, skin reactions, and, in rare cases, liver toxicity. The drug is contraindicated in individuals with liver disease and should be used with caution in those with renal impairment. Terbinafine has a relatively long half-life, allowing for once-daily dosing in oral formulations, which enhances patient compliance. Overall, its efficacy and safety profile make it a widely used option in antifungal therapy.
Formula:C21H25N
InChI:InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+
InChI key:InChIKey=DOMXUEMWDBAQBQ-WEVVVXLNSA-N
SMILES:C(N(C/C=C/C#CC(C)(C)C)C)C=1C2=C(C=CC1)C=CC=C2
Synonyms:
  • 1-Naphthalenemethanamine, N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-, (E)-
  • 1-Naphthalenemethanamine, N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-
  • Da 5505
  • Daskil
  • Eksifine
  • Fungoterbin
  • Lamasil
  • Mycoterbin
  • N-[(2E)-6,6-Dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine
  • Sf 86-327
  • See more synonyms
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