CAS 911637-19-9

GeMigliptin

Description:

GeMigliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor used primarily in the management of type 2 diabetes mellitus. As a member of the gliptin class of medications, it functions by enhancing the levels of incretin hormones, which in turn increases insulin secretion and decreases glucagon release in a glucose-dependent manner. This mechanism helps to improve glycemic control without causing significant hypoglycemia. GeMigliptin is characterized by its selective inhibition of DPP-4, which contributes to its efficacy and safety profile. The compound is typically administered orally and is often used in combination with other antidiabetic agents to achieve better blood sugar management. Its pharmacokinetic properties include a favorable absorption profile and a relatively long half-life, allowing for once-daily dosing. Additionally, GeMigliptin has been studied for its potential cardiovascular benefits, making it a valuable option in the treatment of patients with type 2 diabetes who are at risk for cardiovascular complications.

Formula: C₁₈H₁₉F₈N₅O₂

InChI: InChI=1S/C18H19F8N5O2/c19-16(20)3-1-12(32)31(8-16)6-9(27)5-13(33)30-4-2-10-11(7-30)28-15(18(24,25)26)29-14(10)17(21,22)23/h9H,1-8,27H2/t9-/m0/s1

InChI key: InChIKey=ZWPRRQZNBDYKLH-VIFPVBQESA-N

SMILES: C(F)(F)(F)C1=C2C(CN(C(C[C@@H](CN3CC(F)(F)CCC3=O)N)=O)CC2)=NC(C(F)(F)F)=N1

Synonyms:

• (S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one hydrochloride
• LC15-0444
• Gemigliptin - G10587
• Gemigliptin Hydrochloride
• GeMigliptin WS
• GeMigliptin Tartarate
• Product name:-Gemigliptintartarate
• 1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one
• 2-Piperidinone, 1-[(2S)-2-amino-4-[5,8-dihydro-2,4-bis(trifluoromethyl)pyrido[3,4-d]pyrimidin-7(6H)-yl]-4-oxobutyl]-5,5-difluoro-
• GeMigliptin
• (S)-1-(2-Amino-4-(2,4-bis(trifluoromethyl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one

Gemigliptin

CAS: 911637-19-9

Formula: C₁₈H₁₉F₈N₅O₂

Purity: 98%

Molecular weight: 489.3630

Ref: IN-DA00H0I9

Gemigliptin L-Tartrate

CAS: 1374639-74-3, 911637-19-9

Formula: C₁₈H₁₉F₈N₅O₂·C₄H₆O₆

Molecular weight: 489.37 150.09

Ref: 4Z-G-191002

Gemigliptin

CAS: 911637-19-9

Gemigliptin

Purity: ≥98%

Molecular weight: 489.36g/mol

Ref: 54-BUP09794

Gemigliptin-d4 HCl

CAS: 911637-19-9

Formula: C₁₈H₁₅D₄F₈N₅O₂·HCl

Color and Shape: Off-White Solid

Molecular weight: 493.39 36.46

Ref: 4Z-G-191007

Gemigliptin-d4 Hydrochloride

Controlled Product

CAS: 911637-19-9

Applications Gemigliptin-d4 Hydrochloride is the isotope labelled analog of Gemigliptin Hydrochloride. Gemigliptin Hydrochloride is used in biological studies as a novel dipeptidyl peptidase IV (DPP-IV) inhibitors and potential antidiabetic drug.
References Tanwar, O., et al.: Bioorg. Med. Chem. Lett., 24, 3447 (2014);

Formula: C₁₈D₄H₁₅F₈N₅O₂·HCl

Color and Shape: Neat

Molecular weight: 529.849

Ref: TR-G337002

Gemigliptin

CAS: 911637-19-9

Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)

Formula: C₁₈H₁₉F₈N₅O₂

Purity: 99.72%

Color and Shape: Solid

Molecular weight: 489.36

Ref: TM-T7369