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CAS 911637-19-9

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GeMigliptin

Description:
GeMigliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor used primarily in the management of type 2 diabetes mellitus. As a member of the gliptin class of medications, it functions by enhancing the levels of incretin hormones, which in turn increases insulin secretion and decreases glucagon release in a glucose-dependent manner. This mechanism helps to improve glycemic control without causing significant hypoglycemia. GeMigliptin is characterized by its selective inhibition of DPP-4, which contributes to its efficacy and safety profile. The compound is typically administered orally and is often used in combination with other antidiabetic agents to achieve better blood sugar management. Its pharmacokinetic properties include a favorable absorption profile and a relatively long half-life, allowing for once-daily dosing. Additionally, GeMigliptin has been studied for its potential cardiovascular benefits, making it a valuable option in the treatment of patients with type 2 diabetes who are at risk for cardiovascular complications.
Formula:C18H19F8N5O2
InChI:InChI=1S/C18H19F8N5O2/c19-16(20)3-1-12(32)31(8-16)6-9(27)5-13(33)30-4-2-10-11(7-30)28-15(18(24,25)26)29-14(10)17(21,22)23/h9H,1-8,27H2/t9-/m0/s1
InChI key:InChIKey=ZWPRRQZNBDYKLH-VIFPVBQESA-N
SMILES:C(F)(F)(F)C1=C2C(CN(C(C[C@@H](CN3CC(F)(F)CCC3=O)N)=O)CC2)=NC(C(F)(F)F)=N1
Synonyms:
  • (S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one hydrochloride
  • LC15-0444
  • Gemigliptin - G10587
  • Gemigliptin Hydrochloride
  • GeMigliptin WS
  • GeMigliptin Tartarate
  • Product name:-Gemigliptintartarate
  • 1-[(2S)-2-amino-4-[2,4-bis(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoropiperidin-2-one
  • 2-Piperidinone, 1-[(2S)-2-amino-4-[5,8-dihydro-2,4-bis(trifluoromethyl)pyrido[3,4-d]pyrimidin-7(6H)-yl]-4-oxobutyl]-5,5-difluoro-
  • GeMigliptin
  • (S)-1-(2-Amino-4-(2,4-bis(trifluoromethyl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one
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