CAS 913376-83-7
:AMG-458
Description:
AMG-458, with the CAS number 913376-83-7, is a chemical compound that has been investigated primarily for its potential therapeutic applications. It is classified as a small molecule and functions as a selective antagonist of the neurokinin-1 (NK1) receptor, which is involved in various physiological processes, including pain perception, anxiety, and the regulation of mood. The compound's structure features a specific arrangement of atoms that contributes to its biological activity, allowing it to bind selectively to the NK1 receptor and inhibit its function. This selectivity is crucial for minimizing side effects and enhancing therapeutic efficacy. Research has indicated that AMG-458 may have applications in treating conditions such as depression and anxiety disorders. However, as with many investigational compounds, further studies are necessary to fully understand its pharmacokinetics, safety profile, and overall effectiveness in clinical settings. As of the latest updates, AMG-458 remains a subject of ongoing research within the pharmaceutical field.
Formula:C30H29N5O5
InChI:InChI=1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38H,18H2,1-4H3,(H,32,33,36)
InChI key:GLBZSOQDAOLMGC-UHFFFAOYSA-N
SMILES:CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC
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AMG-458
CAS:AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.Formula:C30H29N5O5Purity:99.91% - 99.98%Color and Shape:SolidMolecular weight:539.5818
