CAS 91421-43-1: 9-Aminocamptothecin

Description: 9-Aminocamptothecin is a synthetic derivative of camptothecin, a compound originally isolated from the bark of the Chinese tree Camptotheca acuminata. It is characterized by its structure, which includes a lactone ring that is crucial for its biological activity. This compound exhibits potent antitumor properties, primarily through its mechanism of action as a topoisomerase I inhibitor, leading to the stabilization of the enzyme-DNA complex and ultimately resulting in DNA damage and apoptosis in cancer cells. 9-Aminocamptothecin is known for its improved solubility and reduced toxicity compared to its parent compound, making it a subject of interest in cancer research and drug development. The substance is typically administered in a clinical setting and has been studied for its efficacy against various types of cancers, including colorectal and ovarian cancers. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for determining its therapeutic potential and safety profile in clinical applications.

Formula: C₂₀H₁₇N₃O₄

InChI: InChI=1S/C20H17N3O4/c1-2-20(26)13-7-16-17-10(6-11-14(21)4-3-5-15(11)22-17)8-23(16)18(24)12(13)9-27-19(20)25/h3-7,26H,2,8-9,21H2,1H3/t20-/m0/s1

InChI key: InChIKey=FUXVKZWTXQUGMW-FQEVSTJZSA-N

SMILES: O=C1OCC=2C(=O)N3C(=CC2C1(O)CC)C=4N=C5C=CC=C(N)C5=CC4C3

Synonyms:

• (4S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-10-amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 10-Amino-4(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)-
• 9-Amino-20-(S)-camptothecin
• Aminocamptothecin
• NSC 603071
• 9-Aminocamptothecin

9-Aminocamptothecin

CAS: 91421-43-1

• Formula: C₂₀H₁₇N₃O₄
• Purity: >95.0%(HPLC)
• Color and Shape: Light yellow to Yellow to Orange powder to crystal
• Molecular weight: 363.37

9-Amino-20(s)-Camptothecin

CAS: 91421-43-1

• Molecular weight: 363.37

9-amino-CPT

CAS: 91421-43-1

• Purity: ≥95%
• Molecular weight: 363.37g/mol

9-amino-CPT

CAS: 91421-43-1

9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.

• Formula: C₂₀H₁₇N₃O₄
• Purity: 97.76% - 99.82%
• Color and Shape: Orange-Yellow Powder
• Molecular weight: 363.37

(S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

CAS: 91421-43-1

• Purity: 95.0%
• Molecular weight: 363.37298583984375

9-Aminocamptothecin

CAS: 91421-43-1

Topoisomerase I inhibitor; more soluble than Camptothecin (FC15450)

• Formula: C₂₀H₁₇N₃O₄
• Purity: Min. 95%
• Color and Shape: Yellow Powder
• Molecular weight: 363.37 g/mol

9-Amino Camptothecin

CAS: 91421-43-1

Applications 9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent. References Hamadeh, H., …

• Formula: C₂₀H₁₇N₃O₄
• Color and Shape: Neat
• Molecular weight: 363.37