CAS 91421-43-1

9-Aminocamptothecin

Description:

9-Aminocamptothecin is a synthetic derivative of camptothecin, a compound originally isolated from the bark of the Chinese tree Camptotheca acuminata. It is characterized by its structure, which includes a lactone ring that is crucial for its biological activity. This compound exhibits potent antitumor properties, primarily through its mechanism of action as a topoisomerase I inhibitor, leading to the stabilization of the enzyme-DNA complex and ultimately resulting in DNA damage and apoptosis in cancer cells. 9-Aminocamptothecin is known for its improved solubility and reduced toxicity compared to its parent compound, making it a subject of interest in cancer research and drug development. The substance is typically administered in a clinical setting and has been studied for its efficacy against various types of cancers, including colorectal and ovarian cancers. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for determining its therapeutic potential and safety profile in clinical applications.

Formula: C₂₀H₁₇N₃O₄

InChI: InChI=1S/C20H17N3O4/c1-2-20(26)13-7-16-17-10(6-11-14(21)4-3-5-15(11)22-17)8-23(16)18(24)12(13)9-27-19(20)25/h3-7,26H,2,8-9,21H2,1H3/t20-/m0/s1

InChI key: InChIKey=FUXVKZWTXQUGMW-FQEVSTJZSA-N

SMILES: C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC=CC5N)COC1=O

Synonyms:

• (4S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (4S)-10-amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 10-Amino-4(S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (4S)-
• 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)-
• 9-Amino-20-(S)-camptothecin
• Aminocamptothecin
• NSC 603071
• 9-Aminocamptothecin

9-Aminocamptothecin

CAS: 91421-43-1

Formula: C₂₀H₁₇N₃O₄

Purity: >95.0%(HPLC)

Color and Shape: Light yellow to Yellow to Orange powder to crystal

Molecular weight: 363.37

Ref: 3B-A2063

9-Amino-20(s)-Camptothecin

CAS: 91421-43-1

Molecular weight: 363.37

Ref: 7W-GP0107

9-amino-CPT

CAS: 91421-43-1

9-amino-CPT

Purity: ≥95%

Molecular weight: 363.37g/mol

Ref: 54-BUP02037

9-amino-CPT

CAS: 91421-43-1

9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.

Formula: C₂₀H₁₇N₃O₄

Purity: 99.13% - 99.82%

Color and Shape: Orange-Yellow Powder

Molecular weight: 363.37

Ref: TM-T3S1957

9-Aminocamptothecin

CAS: 91421-43-1

Topoisomerase I inhibitor; more soluble than Camptothecin (FC15450)

Formula: C₂₀H₁₇N₃O₄

Purity: Min. 95%

Color and Shape: Yellow Powder

Molecular weight: 363.37 g/mol

Ref: 3D-FA74371

9-Aminocamptothecin

CAS: 91421-43-1

Formula: C₂₀H₁₇N₃O₄

Purity: 95%

Molecular weight: 363.373

Ref: 10-F213672

9-Amino Camptothecin

Controlled Product

CAS: 91421-43-1

Applications 9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.
References Hamadeh, H., et al.: Toxicol. Sci., 67, 219 (2002), Dolan, M., et al.: Cancer Res., 64, 4353 (2004), Antony, S., et al.: Cancer Res., 67, 10397 (2007), Pommier, Y., et al.: Mol. Cancer Ther., 8, 1008 (2009),

Formula: C₂₀H₁₇N₃O₄

Color and Shape: Neat

Molecular weight: 363.37

Ref: TR-A603125