CAS 915019-65-7

BEZ 235

Description:

BEZ 235, with the CAS number 915019-65-7, is a small molecule that functions primarily as a dual inhibitor of the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) pathways. These pathways are crucial in regulating cell growth, proliferation, and survival, making BEZ 235 of interest in cancer research and treatment. The compound exhibits a specific structure that allows it to effectively bind to the active sites of the targeted kinases, thereby inhibiting their activity. This inhibition can lead to reduced tumor growth and enhanced apoptosis in cancer cells. BEZ 235 has been studied in various preclinical and clinical settings, particularly for its potential efficacy against certain types of tumors that exhibit aberrant activation of the PI3K/mTOR signaling pathway. Additionally, its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are important for determining its therapeutic potential and safety profile in clinical applications.

Formula: C₃₀H₂₃N₅O

InChI: InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3

InChI key: InChIKey=JOGKUKXHTYWRGZ-UHFFFAOYSA-N

SMILES: O=C1N(C=2C=3C(N=CC2N1C)=CC=C(C3)C4=CC5=C(N=C4)C=CC=C5)C6=CC=C(C(C#N)(C)C)C=C6

Synonyms:

• 2-Methyl-2-[3-Methyl-2-Oxo-8-(3-Quinolinyl)-1-Imidazo[4,5-C]Quinolinyl]Propanenitrile
• 2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile
• 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-1H,2H,3H-imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile
• 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile
• 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethylbenzeneacetonitrile
• Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-
• Bez 23
• Bez 235
• Bez235
• Dactolisib
• Nvp-Bez 235
• Nvp-Bez 235Nx
• Nvpbe 235

BEZ235 (NVP-BEZ235, Dactolisib)

CAS: 915019-65-7

Formula: C₂₄H₁₉N₅O

Purity: %

Color and Shape: Solid

Molecular weight: 393.4406

Ref: IN-DA00GRUY

2-Methyl-2-(4-(3-Methyl-2-Oxo-8-(Quinolin-3-yl)-2,3-Dihydro-1H-Imidazo[4,5-c]Quinolin-1-yl)Phenyl)Propanenitrile

CAS: 915019-65-7

2-Methyl-2-(4-(3-Methyl-2-Oxo-8-(Quinolin-3-yl)-2,3-Dihydro-1H-Imidazo[4,5-c]Quinolin-1-yl)Phenyl)Propanenitrile

Purity: 97%

Molecular weight: 469.54g/mol

Ref: 54-OR1010539

Dactolisib

CAS: 915019-65-7

Dactolisib

Purity: ≥95%

Molecular weight: 469.54g/mol

Ref: 54-BUP14381

Dactolisib (NVP-BEZ 235)

CAS: 915019-65-7

Formula: C₃₀H₂₃N₅O

Molecular weight: 469.55

Ref: 4Z-K-031066

Dactolisib

CAS: 915019-65-7

Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).

Formula: C₃₀H₂₃N₅O

Purity: 97.64% - 99.85%

Color and Shape: Solid

Molecular weight: 469.54

Ref: TM-T2235

NVP-BEZ235

CAS: 915019-65-7

Ref: 7W-GW9334

NVP BEZ 235

CAS: 915019-65-7

Dual PI3K/mTOR inhibitor

Formula: C₃₀H₂₃N₅O

Purity: Min. 95%

Color and Shape: White/Off-White Solid

Molecular weight: 469.54 g/mol

Ref: 3D-FD26487

NVP-BEZ 235

Controlled Product

CAS: 915019-65-7

Applications Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR. Potent PI3K/mTOR Dual Inhibitor.
References Konstantinidou, G., et al.: Cancer Res., 69, 7644 (2009), Frederick, R., et al.: Bioorg. Med. Chem. Lett., 19, 5842 (2009), Pollizzi, K., et al.: Mol. Cancer, 8 (2009),

Formula: C₃₀H₂₃N₅O

Color and Shape: Neat

Molecular weight: 469.54

Ref: TR-N925750