CAS 915019-65-7
:BEZ 235
Description:
BEZ 235, with the CAS number 915019-65-7, is a small molecule that functions primarily as a dual inhibitor of the phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) pathways. These pathways are crucial in regulating cell growth, proliferation, and survival, making BEZ 235 of interest in cancer research and treatment. The compound exhibits a specific structure that allows it to effectively bind to the active sites of the targeted kinases, thereby inhibiting their activity. This inhibition can lead to reduced tumor growth and enhanced apoptosis in cancer cells. BEZ 235 has been studied in various preclinical and clinical settings, particularly for its potential efficacy against certain types of tumors that exhibit aberrant activation of the PI3K/mTOR signaling pathway. Additionally, its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion, are important for determining its therapeutic potential and safety profile in clinical applications.
Formula:C30H23N5O
InChI:InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
InChI key:InChIKey=JOGKUKXHTYWRGZ-UHFFFAOYSA-N
SMILES:O=C1N(C=2C=3C(N=CC2N1C)=CC=C(C3)C4=CC5=C(N=C4)C=CC=C5)C6=CC=C(C(C#N)(C)C)C=C6
Synonyms:- 2-Methyl-2-[3-Methyl-2-Oxo-8-(3-Quinolinyl)-1-Imidazo[4,5-C]Quinolinyl]Propanenitrile
- 2-Methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile
- 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-1H,2H,3H-imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile
- 2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile
- 4-[2,3-Dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethylbenzeneacetonitrile
- Benzeneacetonitrile, 4-[2,3-dihydro-3-methyl-2-oxo-8-(3-quinolinyl)-1H-imidazo[4,5-c]quinolin-1-yl]-α,α-dimethyl-
- Bez 23
- Bez 235
- Bez235
- Dactolisib
- Nvp-Bez 235
- Nvp-Bez 235Nx
- Nvpbe 235
- See more synonyms
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2-Methyl-2-(4-(3-Methyl-2-Oxo-8-(Quinolin-3-yl)-2,3-Dihydro-1H-Imidazo[4,5-c]Quinolin-1-yl)Phenyl)Propanenitrile
CAS:2-Methyl-2-(4-(3-Methyl-2-Oxo-8-(Quinolin-3-yl)-2,3-Dihydro-1H-Imidazo[4,5-c]Quinolin-1-yl)Phenyl)PropanenitrileFormula:C30H23N5OPurity:97%Color and Shape:SolidMolecular weight:469.54BEZ235 (NVP-BEZ235, Dactolisib)
CAS:Formula:C24H19N5OPurity:%Color and Shape:SolidMolecular weight:393.4406Dactolisib
CAS:2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrileFormula:C30H23N5OPurity:98+%Molecular weight:469.54Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Formula:C30H23N5OPurity:97.64% - 99.85%Color and Shape:SolidMolecular weight:469.5365NVP BEZ 235
CAS:Dual PI3K/mTOR inhibitorFormula:C30H23N5OPurity:Min. 95%Color and Shape:White/Off-White SolidMolecular weight:469.54 g/molNVP-BEZ 235
CAS:Controlled ProductApplications Inhibitor of phosphatidylinositol 3-kinases, P13K and mTOR. Potent PI3K/mTOR Dual Inhibitor.
References Konstantinidou, G., et al.: Cancer Res., 69, 7644 (2009), Frederick, R., et al.: Bioorg. Med. Chem. Lett., 19, 5842 (2009), Pollizzi, K., et al.: Mol. Cancer, 8 (2009),Formula:C30H23N5OColor and Shape:NeatMolecular weight:469.54
