CAS 916151-99-0

APTO-253

CAS: 916151-99-0

APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.

Formula: C₂₂H₁₄FN₅

Purity: 98.73%

Color and Shape: Solid

Molecular weight: 367.38

Ref: TM-T10352

LOR 253

CAS: 916151-99-0

Formula: C₂₂H₁₄FN₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 367.3785

Ref: IN-DA00GU3Z

APTO-253

CAS: 916151-99-0

APTO-253

Purity: ≥98%

Molecular weight: 367.38g/mol

Ref: 54-BUP02400

2-(5-Fluoro-2-Methyl-1H-Indol-3-Yl)-1H-Imidazo[4,5-F][1,10]Phenanthroline

CAS: 916151-99-0

2-(5-Fluoro-2-Methyl-1H-Indol-3-Yl)-1H-Imidazo[4,5-F][1,10]Phenanthroline

Purity: 98%

Molecular weight: 367.38g/mol

Ref: 54-PC108532

APTO 253

CAS: 916151-99-0

Induces Kruppel like factor 4 (KLF4) and reduces the expression of MYC.  Anti-tumor activity of APTO 253 has been demonstrated in AML and haematological malignancies. Inducing KLP4 expression in ovarian cancer cells using APT0 253 sensitises cells to cisplatin  and paclitaxel. BRCA1/2-deficient cancer cells are hypersensitive to APTO 253, which mediates its action by causing DNA damage.

Formula: C₂₂H₁₄FN₅

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 367.38 g/mol

Ref: 3D-BA166663