CAS 916151-99-0

Formula: C22H14FN5

InChI: InChI=1S/C22H14FN5/c1-11-17(15-10-12(23)6-7-16(15)26-11)22-27-20-13-4-2-8-24-18(13)19-14(21(20)28-22)5-3-9-25-19/h2-10,26H,1H3,(H,27,28)

InChI key: NIRXBXIPHUTNNI-UHFFFAOYSA-N

SMILES: CC1=C(C2=C(N1)C=CC(=C2)F)C3=NC4=C5C=CC=NC5=C6C(=C4N3)C=CC=N6

APTO-253

CAS: 916151-99-0

APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.

Formula: C₂₂H₁₄FN₅

Purity: 98.73%

Color and Shape: Yellow Solid

Molecular weight: 367.3785

Ref: TM-T10352

APTO-253

CAS: 916151-99-0

APTO-253

Formula: C₂₂H₁₄FN₅

Purity: 98.5%

Molecular weight: 367.38

Ref: 54-BUP02400

2-(5-Fluoro-2-Methyl-1H-Indol-3-Yl)-1H-Imidazo[4,5-F][1,10]Phenanthroline

CAS: 916151-99-0

2-(5-Fluoro-2-Methyl-1H-Indol-3-Yl)-1H-Imidazo[4,5-F][1,10]Phenanthroline

Formula: C₂₂H₁₄FN₅

Purity: ≥98%

Molecular weight: 367.38

Ref: 54-PC108532

2-(5-Fluoro-2-Methyl-1H-Indol-3-Yl)-1H-Imidazo[4,5-F][1,10]Phenanthroline

CAS: 916151-99-0

Formula: C₂₂H₁₄FN₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 367.3785

Ref: IN-DA00GU3Z

APTO-253

CAS: 916151-99-0

2-(5-Fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline

Formula: C₂₂H₁₄FN₅

Purity: 98%

Molecular weight: 367.38

Ref: IN-DG631002

APTO 253

CAS: 916151-99-0

Induces Kruppel like factor 4 (KLF4) and reduces the expression of MYC.  Anti-tumor activity of APTO 253 has been demonstrated in AML and haematological malignancies. Inducing KLP4 expression in ovarian cancer cells using APT0 253 sensitises cells to cisplatin  and paclitaxel. BRCA1/2-deficient cancer cells are hypersensitive to APTO 253, which mediates its action by causing DNA damage.

Formula: C₂₂H₁₄FN₅

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 367.38 g/mol

Ref: 3D-BA166663