CAS 923287-50-7

Opicapone

Description:

Opicapone is a chemical compound primarily used as an adjunct treatment for patients with Parkinson's disease who are experiencing motor fluctuations while on stable doses of levodopa. It functions as a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), an enzyme that metabolizes levodopa, thereby increasing its bioavailability and prolonging its therapeutic effects. Opicapone is characterized by its high specificity for COMT, which minimizes potential side effects associated with non-selective inhibitors. The compound is typically administered orally and is known for its favorable pharmacokinetic profile, including a long half-life that allows for once-daily dosing. Its chemical structure includes a phenolic moiety, contributing to its activity as a COMT inhibitor. Opicapone has been shown to improve motor function in clinical studies, making it a valuable option in the management of Parkinson's disease. As with any medication, it is essential to monitor for potential side effects, which may include dyskinesia, nausea, and other gastrointestinal disturbances.

Formula: C₁₅H₁₀Cl₂N₄O₆

InChI: InChI=1S/C15H10Cl2N4O6/c1-5-10(13(17)20(24)6(2)11(5)16)14-18-15(27-19-14)7-3-8(21(25)26)12(23)9(22)4-7/h3-4,22-23H,1-2H3

InChI key: InChIKey=ASOADIZOVZTJSR-UHFFFAOYSA-N

SMILES: CC=1C(C=2N=C(ON2)C3=CC(N(=O)=O)=C(O)C(O)=C3)=C(Cl)N(=O)=C(C)C1Cl

Synonyms:

• 1,2-Benzenediol, 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-
• 2,5-Dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide
• 5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxido-3-pyridinyl)-1,2,4-oxadiazol-5-yl]-3-nitro-1,2-benzenediol
• 5-[3-(2,5-Dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-3-nitrobenzene-1,2-diol
• Bia 9-1067
• Ongentys
• Opicapone

Opicapone

CAS: 923287-50-7

Formula: C₁₅H₁₀Cl₂N₄O₆

Purity: %

Color and Shape: Solid

Molecular weight: 413.1691

Ref: IN-DA00GU54

Opicapone

CAS: 923287-50-7

Opicapone (BIA 9-1067), a potent COMT inhibitor for Parkinson's studies, lowers cell ATP (IC50: 98 μM).

Formula: C₁₅H₁₀Cl₂N₄O₆

Purity: 98.17% - 99.36%

Color and Shape: Solid

Molecular weight: 413.169

Ref: TM-T16398

Opicapone

CAS: 923287-50-7

Opicapone

Formula: C₁₅H₁₀Cl₂N₄O₆

Purity: ≥95%

Molecular weight: 413.17

Ref: 54-BUP05595

2,5-Dichloro-3-(5-(3,4-Dihydroxy-5-Nitrophenyl)-1,2,4-Oxadiazol-3-Yl)-4,6-Dimethylpyridine 1-Oxide

CAS: 923287-50-7

2,5-Dichloro-3-(5-(3,4-Dihydroxy-5-Nitrophenyl)-1,2,4-Oxadiazol-3-Yl)-4,6-Dimethylpyridine 1-Oxide

Formula: C₁₅H₁₀Cl₂N₄O₆

Purity: 99%

Molecular weight: 413.17

Ref: 54-OR1024414

Opicapone

CAS: 923287-50-7

Formula: C₁₅H₁₀Cl₂N₄O₆

Molecular weight: 413.17

Ref: 4Z-O-073001

Opicapone-d6

CAS: 923287-50-7

Formula: C₁₅H₄D₆Cl₂N₄O₆

Molecular weight: 419.20

Ref: 4Z-O-073002

Opicapone

Controlled Product

CAS: 923287-50-7

Formula: C₁₅H₁₀Cl₂N₄O₆

Color and Shape: Neat

Molecular weight: 413.169

Ref: TR-O669450

Opicapone-d6,15N

Controlled Product

CAS: 923287-50-7

Formula: C₁₅H₄D₆Cl₂N₃NO₆

Color and Shape: Neat

Molecular weight: 420.2

Ref: TR-O669452

Opicapone

CAS: 923287-50-7

Formula: C₁₅H₁₀Cl₂N₄O₆

Molecular weight: 413.2

Ref: BE-RMCO052000

Opicapone

CAS: 923287-50-7

2,5-Dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide

Formula: C₁₅H₁₀Cl₂N₄O₆

Purity: 99%

Molecular weight: 413.17

Ref: IN-DG631013

Opicapone

CAS: 923287-50-7

Purity: 99%

Molecular weight: 413.170

Ref: 10-F843505

Opicapone

CAS: 923287-50-7

Formula: C₁₅H₁₀Cl₂N₄O₆

Molecular weight: 413.17

Ref: ST-EA-CP-O45000